TRIM3 (tripartite motif containing 3)

2009-05-01  

Identity

HGNC
TRIM3
LOCATION
11p15.4
LOCUSID
10612
ALIAS
BERP,HAC1,RNF22,RNF97
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10612
MIM: 605493
HGNC: 10064
Ensembl: ENSG00000110171

Variants:

dbSNP: 10612
ClinVar: 10612
TCGA: ENSG00000110171
COSMIC: TRIM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110171ENST00000345851O75382
ENSG00000110171ENST00000359518O75382
ENSG00000110171ENST00000525074O75382
ENSG00000110171ENST00000528227E9PMK8
ENSG00000110171ENST00000529529E9PMW5
ENSG00000110171ENST00000536344O75382
ENSG00000110171ENST00000639856A0A1W2PPI7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
157721612005CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling.45
249470432014Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma.27
265146222015TRIM-NHL proteins in development and disease.24
192505372009Loss of heterozygosity of TRIM3 in malignant gliomas.23
233184512014TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).18
205431352010Identification of BERP (brain-expressed RING finger protein) as a p53 target gene that modulates seizure susceptibility through interacting with GABA(A) receptors.13
268934792016Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.11
300313922018Exosomal TRIM3 is a novel marker and therapy target for gastric cancer.11
201733062010Glucocorticoid-induced gene tripartite motif-containing 63 (TRIM63) promotes differentiation of osteoblastic cells.7

Citation

Dessen P

TRIM3 (tripartite motif containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50894/trim3