TRIM39 (tripartite motif containing 39)

2014-11-01  

Identity

HGNC
TRIM39
LOCATION
6p22.1
LOCUSID
56658
ALIAS
RNF23,TFP,TRIM39B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56658
MIM: 605700
HGNC: 10065
Ensembl: ENSG00000204599

Variants:

dbSNP: 56658
ClinVar: 56658
TCGA: ENSG00000204599
COSMIC: TRIM39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204599ENST00000376656Q9HCM9
ENSG00000204599ENST00000376656A0A024RCP5
ENSG00000204599ENST00000376659Q9HCM9
ENSG00000204599ENST00000376659A0A024RCR1
ENSG00000204599ENST00000396547Q9HCM9
ENSG00000204599ENST00000396547A0A024RCP5
ENSG00000204599ENST00000396548Q9HCM9
ENSG00000204599ENST00000396548A0A024RCR1
ENSG00000204599ENST00000396551Q9HCM9
ENSG00000204599ENST00000396551A0A024RCR1
ENSG00000204599ENST00000420746H0Y735
ENSG00000204599ENST00000428404A2AAZ3
ENSG00000204599ENST00000428555A2AAZ2
ENSG00000204599ENST00000428728A2AAZ6
ENSG00000204599ENST00000440271A2AAZ4
ENSG00000204599ENST00000458516A2AAZ5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
191002602009TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.18
232132602012Ubiquitylation of p53 by the APC/C inhibitor Trim39.14
208757972010TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26.12
232132512012TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.12
263635542016TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.7
237078102013TRIM39R, but not TRIM39B, regulates type I interferon response.3

Citation

Dessen P

TRIM39 (tripartite motif containing 39)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75151/trim39