TRIM5 (tripartite motif containing 5)

2007-02-01  

Identity

HGNC
TRIM5
LOCATION
11p15.4
LOCUSID
85363
ALIAS
RNF88,TRIM5alpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 85363
MIM: 608487
HGNC: 16276
Ensembl: ENSG00000132256

Variants:

dbSNP: 85363
ClinVar: 85363
TCGA: ENSG00000132256
COSMIC: TRIM5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132256ENST00000380027Q9C035
ENSG00000132256ENST00000380034Q9C035
ENSG00000132256ENST00000396847Q9C035
ENSG00000132256ENST00000412903E7EQQ5
ENSG00000132256ENST00000419850C9JWN8
ENSG00000132256ENST00000433961Q9C035
ENSG00000132256ENST00000438025H7C134

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166123207overall survivalDiseaseVariantAnnotationassociatedPD
PA445204Ovarian NeoplasmsDiseaseVariantAnnotationassociatedPD
PA448803carboplatinChemicalVariantAnnotationassociatedPD
PA450761paclitaxelChemicalVariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
149857642004The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.890
149857642004The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.890
215125732011TRIM5 is an innate immune sensor for the retrovirus capsid lattice.283
152496902004Trim5alpha protein restricts both HIV-1 and murine leukemia virus.219
156493692005A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction.214
152496852004Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha.201
157090332005Species-specific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction.199
152496872004The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities.191
152805392004TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells.161
211874192011Hexagonal assembly of a restricting TRIM5alpha protein.138

Citation

Dessen P

TRIM5 (tripartite motif containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43965/trim5