TRIM50 (tripartite motif containing 50)

2021-06-01  

Identity

HGNC
TRIM50
LOCATION
7q11.23
LOCUSID
135892
ALIAS
TRIM50A

Other Information

Locus ID:

NCBI: 135892
MIM: 612548
HGNC: 19017
Ensembl: ENSG00000146755

Variants:

dbSNP: 135892
ClinVar: 135892
TCGA: ENSG00000146755
COSMIC: TRIM50

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146755ENST00000333149Q86XT4
ENSG00000146755ENST00000333149Q2M204
ENSG00000146755ENST00000453152Q86XT4
ENSG00000146755ENST00000453152Q2M204

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
227923222012The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.23
183984352008Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase.15
296043082018TRIM50 regulates Beclin 1 proautophagic activity.12
243089622014HDAC6 mediates the acetylation of TRIM50.4
297895832018TRIM50 suppressed hepatocarcinoma progression through directly targeting SNAIL for ubiquitous degradation.4

Citation

Dessen P

TRIM50 (tripartite motif containing 50)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58338/trim50