TRIM59 (tripartite motif containing 59)

2003-06-01  

Identity

HGNC
TRIM59
LOCATION
3q25.33
LOCUSID
286827
ALIAS
IFT80L,MRF1,RNF104,TRIM57,TSBF1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 286827
MIM: 616148
HGNC: 30834
Ensembl: ENSG00000213186

Variants:

dbSNP: 286827
ClinVar: 286827
TCGA: ENSG00000213186
COSMIC: TRIM59

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213186ENST00000309784Q8IWR1
ENSG00000213186ENST00000468542C9JNB9
ENSG00000213186ENST00000471155C9IZE0
ENSG00000213186ENST00000471396C9JE08
ENSG00000213186ENST00000479460C9J614
ENSG00000213186ENST00000494486C9J9F0
ENSG00000213186ENST00000496222C9IY67
ENSG00000213186ENST00000543469F5GZP3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
250461642014TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53.47
265990822015TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.34
225881742012TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.18
285349832017TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathway.13
302316672018TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.7
305852702018TRIM59 Is a Novel Marker of Poor Prognosis and Promotes Malignant Progression of Ovarian Cancer by Inducing Annexin A2 Expression.6
294662462018Modified aging of elite athletes revealed by analysis of epigenetic age markers.2
314888272019CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.2
305159652019An TRIM59-CDK6 axis regulates growth and metastasis of lung cancer.1
120956972002Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1.0

Citation

Dessen P

TRIM59 (tripartite motif containing 59)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42711/trim59