TRIM6 (tripartite motif containing 6)

2014-11-01  

Identity

HGNC
TRIM6
LOCATION
11p15.4
LOCUSID
117854
ALIAS
RNF89
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 117854
MIM: 607564
HGNC: 16277
Ensembl: ENSG00000121236

Variants:

dbSNP: 117854
ClinVar: 117854
TCGA: ENSG00000121236
COSMIC: TRIM6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121236ENST00000278302Q9C030
ENSG00000121236ENST00000380097Q9C030
ENSG00000121236ENST00000380107E9PFM0
ENSG00000121236ENST00000424369C9JNQ0
ENSG00000121236ENST00000445329Q9C030
ENSG00000121236ENST00000506134Q9C030
ENSG00000121236ENST00000507320Q9C030
ENSG00000121236ENST00000515022Q9C030
ENSG00000121236ENST00000621176E9PFM0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
248822182014Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.50
167753072006Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains.35
276225052016The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response.26
286797612017The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.18
316949462020VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection.3

Citation

Dessen P

TRIM6 (tripartite motif containing 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75172/trim6