Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRIM63 (tripartite motif containing 63)

Identity

Alias_namesRNF28
ring finger protein 28
tripartite motif containing 63, E3 ubiquitin protein ligase
Alias_symbol (synonym)MURF-1
IRF
SMRZ
Other aliasMURF1
MURF2
HGNC (Hugo) TRIM63
LocusID (NCBI) 84676
Atlas_Id 42134
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 26051305 and ends at 26067634 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SIRT2 (19q13.2) / TRIM63 (1p36.11)TRIM63 (1p36.11) / DTWD2 (5q23.1)TRIM63 (1p36.11) / PTMA (2q37.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TRIM63   16007
LRG (Locus Reference Genomic)LRG_757
Cards
Entrez_Gene (NCBI)TRIM63  84676  tripartite motif containing 63
AliasesIRF; MURF1; MURF2; RNF28; 
SMRZ
GeneCards (Weizmann)TRIM63
Ensembl hg19 (Hinxton)ENSG00000158022 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158022 [Gene_View]  ENSG00000158022 [Sequence]  chr1:26051305-26067634 [Contig_View]  TRIM63 [Vega]
ICGC DataPortalENSG00000158022
TCGA cBioPortalTRIM63
AceView (NCBI)TRIM63
Genatlas (Paris)TRIM63
WikiGenes84676
SOURCE (Princeton)TRIM63
Genetics Home Reference (NIH)TRIM63
Genomic and cartography
GoldenPath hg38 (UCSC)TRIM63  -     chr1:26051305-26067634 -  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIM63  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathTRIM63 - 1p36.11 [CytoView hg19]  TRIM63 - 1p36.11 [CytoView hg38]
Genome Data Viewer NCBITRIM63 [Mapview hg19]  
OMIM606131   
Gene and transcription
Genbank (Entrez)AF353673 AF361946 AI351421 AJ276484 AK056942
RefSeq transcript (Entrez)NM_032588
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIM63
Alternative Splicing GalleryENSG00000158022
Gene ExpressionTRIM63 [ NCBI-GEO ]   TRIM63 [ EBI - ARRAY_EXPRESS ]   TRIM63 [ SEEK ]   TRIM63 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIM63 [ Firebrowse - Broad ]
GenevisibleExpression of TRIM63 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84676
GTEX Portal (Tissue expression)TRIM63
Human Protein AtlasENSG00000158022-TRIM63 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969Q1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969Q1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969Q1
Splice isoforms : SwissVarQ969Q1
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ969Q1
Domaine pattern : Prosite (Expaxy)COS (PS51262)    ZF_BBOX (PS50119)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)COS_domain    TRIM63_RING-HC    Znf-RING_LisH    Znf_B-box    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)zf-B_box (PF00643)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00643    pfam13445   
Domain families : Smart (EMBL)BBOX (SM00336)  RING (SM00184)  
Conserved Domain (NCBI)TRIM63
DMDM Disease mutations84676
PDB (RSDB)2D8U    3DDT    4M3L   
PDB Europe2D8U    3DDT    4M3L   
PDB (PDBSum)2D8U    3DDT    4M3L   
PDB (IMB)2D8U    3DDT    4M3L   
Structural Biology KnowledgeBase2D8U    3DDT    4M3L   
SCOP (Structural Classification of Proteins)2D8U    3DDT    4M3L   
CATH (Classification of proteins structures)2D8U    3DDT    4M3L   
SuperfamilyQ969Q1
Human Protein Atlas [tissue]ENSG00000158022-TRIM63 [tissue]
Peptide AtlasQ969Q1
HPRD05843
IPIIPI00000309   IPI00847788   
Protein Interaction databases
DIP (DOE-UCLA)Q969Q1
IntAct (EBI)Q969Q1
FunCoupENSG00000158022
BioGRIDTRIM63
STRING (EMBL)TRIM63
ZODIACTRIM63
Ontologies - Pathways
QuickGOQ969Q1
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytoplasm  cytoplasm  microtubule  muscle contraction  signal transduction  zinc ion binding  negative regulation of cardiac muscle hypertrophy  skeletal muscle atrophy  response to electrical stimulus involved in regulation of muscle adaptation  protein ubiquitination  protein ubiquitination  Z disc  M band  titin binding  response to glucocorticoid  ubiquitin protein ligase activity  response to interleukin-1  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytoplasm  cytoplasm  microtubule  muscle contraction  signal transduction  zinc ion binding  negative regulation of cardiac muscle hypertrophy  skeletal muscle atrophy  response to electrical stimulus involved in regulation of muscle adaptation  protein ubiquitination  protein ubiquitination  Z disc  M band  titin binding  response to glucocorticoid  ubiquitin protein ligase activity  response to interleukin-1  
NDEx NetworkTRIM63
Atlas of Cancer Signalling NetworkTRIM63
Wikipedia pathwaysTRIM63
Orthology - Evolution
OrthoDB84676
GeneTree (enSembl)ENSG00000158022
Phylogenetic Trees/Animal Genes : TreeFamTRIM63
HOGENOMQ969Q1
Homologs : HomoloGeneTRIM63
Homology/Alignments : Family Browser (UCSC)TRIM63
Gene fusions - Rearrangements
Fusion : QuiverTRIM63
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIM63 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIM63
dbVarTRIM63
ClinVarTRIM63
1000_GenomesTRIM63 
Exome Variant ServerTRIM63
GNOMAD BrowserENSG00000158022
Varsome BrowserTRIM63
Genetic variants : HAPMAP84676
Genomic Variants (DGV)TRIM63 [DGVbeta]
DECIPHERTRIM63 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIM63 
Mutations
ICGC Data PortalTRIM63 
TCGA Data PortalTRIM63 
Broad Tumor PortalTRIM63
OASIS PortalTRIM63 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIM63  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIM63
Mutations and Diseases : HGMDTRIM63
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect TRIM63
DgiDB (Drug Gene Interaction Database)TRIM63
DoCM (Curated mutations)TRIM63 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIM63 (select a term)
intoGenTRIM63
Cancer3DTRIM63 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606131   
Orphanet
DisGeNETTRIM63
MedgenTRIM63
Genetic Testing Registry TRIM63
NextProtQ969Q1 [Medical]
TSGene84676
GENETestsTRIM63
Open Targets GeneticsENSG00000158022  [validation]
snp3D : Map Gene to Disease84676
BioCentury BCIQTRIM63
ClinGenTRIM63
Clinical trials, drugs, therapy
Protein Interactions : CTD84676
Pharm GKB GenePA34431
Clinical trialTRIM63
Miscellaneous
canSAR (ICR)TRIM63 (select the gene name)
HarmonizomeTRIM63
DataMed IndexTRIM63
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIM63
EVEXTRIM63
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:16:44 CEST 2020
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