TRIM63 (tripartite motif containing 63)

2003-12-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
IRF,MURF1,MURF2,RNF28,SMRZ
FUSION GENES

Other Information

Locus ID:

NCBI: 84676
MIM: 606131
HGNC: 16007
Ensembl: ENSG00000158022

Variants:

dbSNP: 84676
ClinVar: 84676
TCGA: ENSG00000158022
COSMIC: TRIM63

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158022ENST00000374272Q969Q1

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
250961802014Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.180
186120452008The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.120
156017792004Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.111
179011162007The temporal responses of protein synthesis, gene expression and cell signalling in human quadriceps muscle and patellar tendon to disuse.89
119276052002Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1.73
228150452013Atrogin-1, MuRF-1, and sarcopenia.63
174786212007Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.61
228219322012Human molecular genetic and functional studies identify TRIM63, encoding Muscle RING Finger Protein 1, as a novel gene for human hypertrophic cardiomyopathy.47
124149932002Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein.42
198505792010Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.39

Citation

Dessen P

TRIM63 (tripartite motif containing 63)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42134/trim63