TRIM71 (tripartite motif containing 71)

2013-04-01  

Identity

HGNC
TRIM71
LOCATION
3p22.3
LOCUSID
131405
ALIAS
HYDCC1,LIN-41,LIN41

Other Information

Locus ID:

NCBI: 131405
MIM: 618570
HGNC: 32669
Ensembl: ENSG00000206557

Variants:

dbSNP: 131405
ClinVar: 131405
TCGA: ENSG00000206557
COSMIC: TRIM71

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000206557ENST00000383763Q2Q1W2

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
227354512012Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation.54
178902402007Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development.28
265146222015TRIM-NHL proteins in development and disease.24
246029722014The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein.16
230972742013The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing.14
278218012016TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling.5
313714372019The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1.3
238920922013Exploration of deleterious single nucleotide polymorphisms in the components of human P bodies: an in silico approach.2
317327462019The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.1

Citation

Dessen P

TRIM71 (tripartite motif containing 71)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53250/trim71