TRIM8 (tripartite motif containing 8)

2003-02-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
GERP,RNF27
FUSION GENES

Other Information

Locus ID:

NCBI: 81603
MIM: 606125
HGNC: 15579
Ensembl: ENSG00000171206

Variants:

dbSNP: 81603
ClinVar: 81603
TCGA: ENSG00000171206
COSMIC: TRIM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171206ENST00000302424A0A2U3TZI0
ENSG00000171206ENST00000462202R4GN03
ENSG00000171206ENST00000642304A0A2R8YCF6
ENSG00000171206ENST00000642664A0A2R8YFP1
ENSG00000171206ENST00000643100A0A2R8YD00
ENSG00000171206ENST00000643376A0A2R8Y5K0
ENSG00000171206ENST00000643721Q9BZR9
ENSG00000171206ENST00000644914A0A2R8Y580
ENSG00000171206ENST00000645961A0A2R8Y500

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
220840992011Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination.49
121634972002TRIM8/GERP RING finger protein interacts with SOCS-1.28
205161482010TRIM8 modulates STAT3 activity through negative regulation of PIAS3.19
222621832012TRIM8 modulates p53 activity to dictate cell cycle arrest.17
260779892015TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival.16
216896892011TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells.12
252771842014TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma.12
283271522017TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours.10
179005112007Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma.9

Citation

Dessen P

TRIM8 (tripartite motif containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42704/trim8