TRIP12 (thyroid hormone receptor interactor 12)

2012-04-01  

Identity

HGNC
TRIP12
LOCATION
2q36.3
LOCUSID
9320
ALIAS
MRD49,TRIP-12,TRIPC,ULF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9320
MIM: 604506
HGNC: 12306
Ensembl: ENSG00000153827

Variants:

dbSNP: 9320
ClinVar: 9320
TCGA: ENSG00000153827
COSMIC: TRIP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153827ENST00000283943Q14669
ENSG00000153827ENST00000343290F8W9P3
ENSG00000153827ENST00000389044Q14669
ENSG00000153827ENST00000389045Q14669
ENSG00000153827ENST00000409677G5E9G6
ENSG00000153827ENST00000418123H7C2Y1
ENSG00000153827ENST00000428959C9JLJ5
ENSG00000153827ENST00000430954C9JLD7
ENSG00000153827ENST00000435716C9JSX9
ENSG00000153827ENST00000453485H7C1L9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366398312023Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth.1
367470062023The neurodevelopmental and facial phenotype in individuals with a TRIP12 variant.4
371082032023Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.0
366398312023Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth.1
367470062023The neurodevelopmental and facial phenotype in individuals with a TRIP12 variant.4
371082032023Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.0
364301432022Episignature Mapping of TRIP12 Provides Functional Insight into Clark-Baraitser Syndrome.2
364301432022Episignature Mapping of TRIP12 Provides Functional Insight into Clark-Baraitser Syndrome.2
335672682021TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.21
338243122021Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.17
339631762021The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.7
346445452021TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.19
335672682021TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.21
338243122021Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.17
339631762021The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.7

Citation

Dessen P

TRIP12 (thyroid hormone receptor interactor 12)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52672/trip12