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TRIP12 (thyroid hormone receptor interactor 12)

Identity

Alias_symbol (synonym)KIAA0045
Other aliasMRD49
TRIP-12
ULF
HGNC (Hugo) TRIP12
LocusID (NCBI) 9320
Atlas_Id 52672
Location 2q36.3  [Link to chromosome band 2q36]
Location_base_pair Starts at 229763837 and ends at 229922009 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C14orf1 (14q24.3) / TRIP12 (2q36.3)DNER (2q36.3) / TRIP12 (2q36.3)ELL2 (5q15) / TRIP12 (2q36.3)
TRIP12 (2q36.3) / ADK (10q22.2)TRIP12 (2q36.3) / AGFG1 (2q36.3)TRIP12 (2q36.3) / ATP6V1H (8q11.23)
TRIP12 (2q36.3) / KIF1A (2q37.3)TRIP12 (2q36.3) / SLC16A14 (2q36.3)TRIP12 (2q36.3) / SLC4A10 (2q24.2)
TRIP12 (2q36.3) / SP110 (2q37.1)TRIP12 (2q36.3) / TRIP12 (2q36.3)DNER 2q36.3 / TRIP12 2q36.3
TRIP12 2q36.3 / AGFG1 2q36.3TRIP12 2q36.3 / KIF1A 2q37.3TRIP12 2q36.3 / SLC16A14 2q36.3
TRIP12 2q36.3 / SLC4A10 2q24.2TRIP12 2q36.3 / SP110 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(2;2)(q24;q36) TRIP12/SLC4A10
DNER/TRIP12 (2q36)
TRIP12/AGFG1 (2q36)
TRIP12/SLC16A14 (2q36)
t(2;2)(q36;q37) TRIP12/KIF1A
t(2;2)(q36;q37) TRIP12/SP110


External links

Nomenclature
HGNC (Hugo)TRIP12   12306
Cards
Entrez_Gene (NCBI)TRIP12  9320  thyroid hormone receptor interactor 12
AliasesMRD49; TRIP-12; ULF
GeneCards (Weizmann)TRIP12
Ensembl hg19 (Hinxton)ENSG00000153827 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153827 [Gene_View]  ENSG00000153827 [Sequence]  chr2:229763837-229922009 [Contig_View]  TRIP12 [Vega]
ICGC DataPortalENSG00000153827
TCGA cBioPortalTRIP12
AceView (NCBI)TRIP12
Genatlas (Paris)TRIP12
WikiGenes9320
SOURCE (Princeton)TRIP12
Genetics Home Reference (NIH)TRIP12
Genomic and cartography
GoldenPath hg38 (UCSC)TRIP12  -     chr2:229763837-229922009 -  2q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIP12  -     2q36.3   [Description]    (hg19-Feb_2009)
GoldenPathTRIP12 - 2q36.3 [CytoView hg19]  TRIP12 - 2q36.3 [CytoView hg38]
ImmunoBaseENSG00000153827
Mapping of homologs : NCBITRIP12 [Mapview hg19]  TRIP12 [Mapview hg38]
OMIM604506   617752   
Gene and transcription
Genbank (Entrez)AK128481 AK302468 AK310971 BC037956 BC113891
RefSeq transcript (Entrez)NM_001284214 NM_001284215 NM_001284216 NM_001348315 NM_001348316 NM_001348317 NM_001348318 NM_001348319 NM_001348320 NM_001348321 NM_001348322 NM_001348323 NM_001348324 NM_001348325 NM_001348326 NM_001348327 NM_001348328 NM_001348329 NM_001348330 NM_001348331 NM_001348332 NM_001348333 NM_001348334 NM_001348335 NM_001348336 NM_004238
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIP12
Cluster EST : UnigeneHs.601806 [ NCBI ]
CGAP (NCI)Hs.601806
Alternative Splicing GalleryENSG00000153827
Gene ExpressionTRIP12 [ NCBI-GEO ]   TRIP12 [ EBI - ARRAY_EXPRESS ]   TRIP12 [ SEEK ]   TRIP12 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIP12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9320
GTEX Portal (Tissue expression)TRIP12
Human Protein AtlasENSG00000153827-TRIP12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14669   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14669  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14669
Splice isoforms : SwissVarQ14669
PhosPhoSitePlusQ14669
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    WWE (PS50918)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HECT_dom    Hect_E3_ubiquitin_ligase    WWE-dom    WWE_dom_sf   
Domain families : Pfam (Sanger)HECT (PF00632)   
Domain families : Pfam (NCBI)pfam00632   
Domain families : Smart (EMBL)HECTc (SM00119)  
Conserved Domain (NCBI)TRIP12
DMDM Disease mutations9320
Blocks (Seattle)TRIP12
SuperfamilyQ14669
Human Protein Atlas [tissue]ENSG00000153827-TRIP12 [tissue]
Peptide AtlasQ14669
HPRD05144
IPIIPI00871861   IPI00917460   IPI00032342   IPI00783250   IPI00917821   IPI00917965   IPI00916968   IPI00917131   IPI00916070   IPI01015150   
Protein Interaction databases
DIP (DOE-UCLA)Q14669
IntAct (EBI)Q14669
FunCoupENSG00000153827
BioGRIDTRIP12
STRING (EMBL)TRIP12
ZODIACTRIP12
Ontologies - Pathways
QuickGOQ14669
Ontology : AmiGOprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytosol  DNA repair  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  nuclear speck  nuclear speck  regulation of embryonic development  thyroid hormone receptor binding  negative regulation of histone H2A K63-linked ubiquitination  negative regulation of histone H2A K63-linked ubiquitination  negative regulation of double-strand break repair  
Ontology : EGO-EBIprotein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  cytosol  DNA repair  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  nuclear speck  nuclear speck  regulation of embryonic development  thyroid hormone receptor binding  negative regulation of histone H2A K63-linked ubiquitination  negative regulation of histone H2A K63-linked ubiquitination  negative regulation of double-strand break repair  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkTRIP12
Atlas of Cancer Signalling NetworkTRIP12
Wikipedia pathwaysTRIP12
Orthology - Evolution
OrthoDB9320
GeneTree (enSembl)ENSG00000153827
Phylogenetic Trees/Animal Genes : TreeFamTRIP12
HOGENOMQ14669
Homologs : HomoloGeneTRIP12
Homology/Alignments : Family Browser (UCSC)TRIP12
Gene fusions - Rearrangements
Fusion : MitelmanDNER/TRIP12 [2q36.3/2q36.3]  [t(2;2)(q36;q36)]  
Fusion : MitelmanTRIP12/AGFG1 [2q36.3/2q36.3]  [t(2;2)(q36;q36)]  
Fusion : MitelmanTRIP12/KIF1A [2q36.3/2q37.3]  [t(2;2)(q36;q37)]  
Fusion : MitelmanTRIP12/SLC16A14 [2q36.3/2q36.3]  [t(2;2)(q36;q36)]  
Fusion : MitelmanTRIP12/SLC4A10 [2q36.3/2q24.2]  [t(2;2)(q24;q36)]  
Fusion : MitelmanTRIP12/SP110 [2q36.3/2q37.1]  [t(2;2)(q36;q37)]  
Fusion PortalDNER 2q36.3 TRIP12 2q36.3 BRCA
Fusion PortalTRIP12 2q36.3 AGFG1 2q36.3 BRCA
Fusion PortalTRIP12 2q36.3 KIF1A 2q37.3 LUSC
Fusion PortalTRIP12 2q36.3 SLC16A14 2q36.3 KIRC LUAD
Fusion PortalTRIP12 2q36.3 SLC4A10 2q24.2 BRCA
Fusion PortalTRIP12 2q36.3 SP110 2q37.1 BRCA
Fusion : QuiverTRIP12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIP12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIP12
dbVarTRIP12
ClinVarTRIP12
1000_GenomesTRIP12 
Exome Variant ServerTRIP12
ExAC (Exome Aggregation Consortium)ENSG00000153827
GNOMAD BrowserENSG00000153827
Varsome BrowserTRIP12
Genetic variants : HAPMAP9320
Genomic Variants (DGV)TRIP12 [DGVbeta]
DECIPHERTRIP12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIP12 
Mutations
ICGC Data PortalTRIP12 
TCGA Data PortalTRIP12 
Broad Tumor PortalTRIP12
OASIS PortalTRIP12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIP12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIP12
Mutations and Diseases : HGMDTRIP12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIP12
DgiDB (Drug Gene Interaction Database)TRIP12
DoCM (Curated mutations)TRIP12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIP12 (select a term)
intoGenTRIP12
Cancer3DTRIP12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604506    617752   
Orphanet
DisGeNETTRIP12
MedgenTRIP12
Genetic Testing Registry TRIP12
NextProtQ14669 [Medical]
TSGene9320
GENETestsTRIP12
Target ValidationTRIP12
Huge Navigator TRIP12 [HugePedia]
snp3D : Map Gene to Disease9320
BioCentury BCIQTRIP12
ClinGenTRIP12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9320
Chemical/Pharm GKB GenePA36985
Clinical trialTRIP12
Miscellaneous
canSAR (ICR)TRIP12 (select the gene name)
DataMed IndexTRIP12
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIP12
EVEXTRIP12
GoPubMedTRIP12
iHOPTRIP12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:13:12 CET 2019

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