TRIP13 (thyroid hormone receptor interactor 13)

2009-11-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
16E1BP,MVA3,OOMD9

Other Information

Locus ID:

NCBI: 9319
MIM: 604507
HGNC: 12307
Ensembl: ENSG00000071539

Variants:

dbSNP: 9319
ClinVar: 9319
TCGA: ENSG00000071539
COSMIC: TRIP13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071539ENST00000166345Q15645
ENSG00000071539ENST00000513435H0YAL2

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
250126652014Thyroid hormone receptor interacting protein 13 (TRIP13) AAA-ATPase is a novel mitotic checkpoint-silencing protein.53
250922942014Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).46
250780332014TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.40
299737202018Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.28
285539592017Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.27
268324172016TRIP13 Regulates Both the Activation and Inactivation of the Spindle-Assembly Checkpoint.23
263248902015Mode of interaction of TRIP13 AAA-ATPase with the Mad2-binding protein p31comet and with mitotic checkpoint complexes.22
295407292018TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer.16
286593782017The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.14
292088962017Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing.11

Citation

Dessen P

TRIP13 (thyroid hormone receptor interactor 13)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51188/trip13