TRPA1 (transient receptor potential cation channel subfamily A member 1)

2012-09-01  

Identity

HGNC
TRPA1
LOCATION
8q21.11
LOCUSID
8989
ALIAS
ANKTM1,FEPS,FEPS1

Other Information

Locus ID:

NCBI: 8989
MIM: 604775
HGNC: 497
Ensembl: ENSG00000104321

Variants:

dbSNP: 8989
ClinVar: 8989
TCGA: ENSG00000104321
COSMIC: TRPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104321ENST00000262209O75762
ENSG00000104321ENST00000523582H0YAW0

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583

References

Pubmed IDYearTitleCitations
147122382004Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.600
171643272006TRP channel activation by reversible covalent modification.322
258552972015Structure of the TRPA1 ion channel suggests regulatory mechanisms.168
175711672007Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.153
189544672008HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.131
190747432008Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control.126
205471262010A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome.121
193695492009TRPA1 modulates mechanotransduction in cutaneous sensory neurons.120
187759872008The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.105
234152282013A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.94

Citation

Dessen P

TRPA1 (transient receptor potential cation channel subfamily A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52884/trpa1