TRPC1 (transient receptor potential cation channel subfamily C member 1)

2007-02-01  

Identity

HGNC
LOCATION
3q23
LOCUSID
ALIAS
HTRP-1,TRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 7220
MIM: 602343
HGNC: 12333
Ensembl: ENSG00000144935

Variants:

dbSNP: 7220
ClinVar: 7220
TCGA: ENSG00000144935
COSMIC: TRPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144935ENST00000273482P48995
ENSG00000144935ENST00000460401H7C508
ENSG00000144935ENST00000476941P48995
ENSG00000144935ENST00000612385P48995

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Serotonergic synapseKEGGhsa04726
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382777242024Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.0
382777242024Upregulation of TRPC1 protects against high glucose-induced HUVECs dysfunction by inhibiting oxidative stress.0
367975442023Function of TRPC1 in modulating hepatocellular carcinoma progression.2
370624362023Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.1
367975442023Function of TRPC1 in modulating hepatocellular carcinoma progression.2
370624362023Reduction of TRPC1/TRPC3 mediated Ca(2+)-signaling protects oxidative stress-induced COPD.1
349886802022Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.8
349889862022Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.2
351068472022Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.5
358829792022NCX1 coupled with TRPC1 to promote gastric cancer via Ca(2+)/AKT/β-catenin pathway.3
358872662022The TRPC1 Channel Forms a PI3K/CaM Complex and Regulates Pancreatic Ductal Adenocarcinoma Cell Proliferation in a Ca(2+)-Independent Manner.3
359056542022TRPC1 channels regulate the activation of pancreatic stellate cells through ERK1/2 and SMAD2 pathways and perpetuate their pressure-mediated activation.5
349886802022Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.8
349889862022Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1.2
351068472022Dysregulated transient receptor potential channel 1 expression and its correlation with clinical features and survival profile in surgical non-small-cell lung cancer patients.5

Citation

Dessen P

TRPC1 (transient receptor potential cation channel subfamily C member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43870/trpc1