TRPC1 (transient receptor potential cation channel subfamily C member 1)

2007-02-01  

Identity

HGNC
LOCATION
3q23
LOCUSID
ALIAS
HTRP-1,TRP1
FUSION GENES

Other Information

Locus ID:

NCBI: 7220
MIM: 602343
HGNC: 12333
Ensembl: ENSG00000144935

Variants:

dbSNP: 7220
ClinVar: 7220
TCGA: ENSG00000144935
COSMIC: TRPC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144935ENST00000273482P48995
ENSG00000144935ENST00000460401H7C508
ENSG00000144935ENST00000476941P48995
ENSG00000144935ENST00000612385P48995

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Serotonergic synapseKEGGhsa04726
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersREACTOMER-HSA-983695
Muscle contractionREACTOMER-HSA-397014
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890
Cardiac conductionREACTOMER-HSA-5576891
Ion homeostasisREACTOMER-HSA-5578775

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
120323052002Subunit composition of mammalian transient receptor potential channels in living cells.218
172244522007Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.140
189958412008STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction.116
181724972008TRPC channel activation by extracellular thioredoxin.111
183265002008Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels.90
214081962011Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions.90
120605712002Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
179573832008Revisiting TRPC1 and TRPC6 mechanosensitivity.80
168706122006Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores.71

Citation

Dessen P

TRPC1 (transient receptor potential cation channel subfamily C member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43870/trpc1