TRPC3 (transient receptor potential cation channel subfamily C member 3)

2008-03-01  

Identity

HGNC
LOCATION
4q27
LOCUSID
ALIAS
SCA41,TRP3
FUSION GENES

Other Information

Locus ID:

NCBI: 7222
MIM: 602345
HGNC: 12335
Ensembl: ENSG00000138741

Variants:

dbSNP: 7222
ClinVar: 7222
TCGA: ENSG00000138741
COSMIC: TRPC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138741ENST00000264811Q13507
ENSG00000138741ENST00000379645Q13507
ENSG00000138741ENST00000502968D6R902
ENSG00000138741ENST00000506449D6RC49
ENSG00000138741ENST00000513531J3QTB0

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

References

Pubmed IDYearTitleCitations
153588622004Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.149
173605842007Orai proteins interact with TRPC channels and confer responsiveness to store depletion.117
119437852002Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition.74
165375422006TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.73
157443072005Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain.69
156472882005A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.67
159728142005Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells.67
129703632003N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity.66
244532172014Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy.60
126065422003Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels.56

Citation

Dessen P

TRPC3 (transient receptor potential cation channel subfamily C member 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50070/trpc3