TRPC4 (transient receptor potential cation channel subfamily C member 4)

2007-12-01 Affiliation

Identity

HGNC

TRPC4

LOCATION

13q13.3

LOCUSID

7223

ALIAS

HTRP-4,HTRP4,TRP4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7223
MIM: 603651
HGNC: 12336
Ensembl: ENSG00000133107

Variants:

dbSNP: 7223
ClinVar: 7223
TCGA: ENSG00000133107
COSMIC: TRPC4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133107	ENST00000338947	Q9UBN4
ENSG00000133107	ENST00000355779	Q9UBN4
ENSG00000133107	ENST00000358477	Q9UBN4
ENSG00000133107	ENST00000379673	Q9UBN4
ENSG00000133107	ENST00000379679	Q9UBN4
ENSG00000133107	ENST00000379705	Q9UBN4
ENSG00000133107	ENST00000426868	Q3MHB9
ENSG00000133107	ENST00000488717	Q9UBN4
ENSG00000133107	ENST00000625583	Q9UBN4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Stimuli-sensing channels	REACTOME	R-HSA-2672351
TRP channels	REACTOME	R-HSA-3295583
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Netrin-1 signaling	REACTOME	R-HSA-373752
Role of second messengers in netrin-1 signaling	REACTOME	R-HSA-418890

References

Pubmed ID	Year	Title	Citations
15358862	2004	Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.	149
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
16144838	2005	Epidermal growth factor induces tyrosine phosphorylation, membrane insertion, and activation of transient receptor potential channel 4.	36
22457348	2012	Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.	35
16254212	2005	Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.	34
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
12154080	2002	The PDZ-interacting domain of TRPC4 controls its localization and surface expression in HEK293 cells.	29
18021253	2007	Transient potential receptor channel 4 controls thrombospondin-1 secretion and angiogenesis in renal cell carcinoma.	29
28325835	2017	Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.	29
19307462	2009	Interaction between TRPC1/TRPC4 assembly and STIM1 contributes to store-operated Ca2+ entry in mesangial cells.	26

Citation

Dessen P

TRPC4 (transient receptor potential cation channel subfamily C member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49942/trpc4