TRPC6 (transient receptor potential cation channel subfamily C member 6)

2008-08-01  

Identity

HGNC
LOCATION
11q22.1
LOCUSID
ALIAS
FSGS2,TRP6
FUSION GENES

Other Information

Locus ID:

NCBI: 7225
MIM: 603652
HGNC: 12338
Ensembl: ENSG00000137672

Variants:

dbSNP: 7225
ClinVar: 7225
TCGA: ENSG00000137672
COSMIC: TRPC6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137672ENST00000344327Q9Y210
ENSG00000137672ENST00000348423Q9Y210
ENSG00000137672ENST00000360497Q9Y210
ENSG00000137672ENST00000532133E9PJN4

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377748992024The Multifunctional TRPC6 Protein: Significance in the Field of Cardiovascular Studies.0
379806532024Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.0
385655152024[Expansion of the genotypic and phenotypic spectrum and treatment of four children with Steroid-resistant nephrotic syndrome due to variants of TRPC6 gene].0
377748992024The Multifunctional TRPC6 Protein: Significance in the Field of Cardiovascular Studies.0
379806532024Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150.0
385655152024[Expansion of the genotypic and phenotypic spectrum and treatment of four children with Steroid-resistant nephrotic syndrome due to variants of TRPC6 gene].0
362801862023TRPC6-protein expression in the elderly and in liver disease.0
364502022023Is Zn(2+) the new Ca(2+) for TRPC6 channels in the myocardium?0
367467702023Improvement of platelet preservation by inhibition of TRPC6.0
369444752023Familial systemic lupus erythematosus associated with a loss-of-function mutation in TRPC6.0
376157492023An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis.0
380036082023A Putative Role for TRPC6 in Immune-Mediated Kidney Injury.0
380690812023TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury.0
362801862023TRPC6-protein expression in the elderly and in liver disease.0
364502022023Is Zn(2+) the new Ca(2+) for TRPC6 channels in the myocardium?0

Citation

Dessen P

TRPC6 (transient receptor potential cation channel subfamily C member 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50292/trpc6