TRPC7 (transient receptor potential cation channel subfamily C member 7)

2016-10-01  

Identity

HGNC
TRPC7
LOCATION
5q31.1
LOCUSID
57113
ALIAS
TRP7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57113
HGNC: 20754
Ensembl: ENSG00000069018

Variants:

dbSNP: 57113
ClinVar: 57113
TCGA: ENSG00000069018
COSMIC: TRPC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069018ENST00000352189Q9HCX4
ENSG00000069018ENST00000378459Q9HCX4
ENSG00000069018ENST00000502753Q70T25
ENSG00000069018ENST00000503275A1A4Z5
ENSG00000069018ENST00000513104Q9HCX4
ENSG00000069018ENST00000514963Q70T24

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Platelet calcium homeostasisREACTOMER-HSA-418360
Elevation of cytosolic Ca2+ levelsREACTOMER-HSA-139853
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Role of second messengers in netrin-1 signalingREACTOMER-HSA-418890

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
159728142005Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
118051192002Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.35
180211752007Importance of melastatin-like transient receptor potential 7 and cations (magnesium, calcium) in human osteoblast-like cell proliferation.27
244704872014PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.26
192407912009Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis.24
153423422004Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells.21
161230402005The role of canonical transient receptor potential 7 in B-cell receptor-activated channels.19
167415132006TRPC7 is a receptor-operated DAG-activated channel in human keratinocytes.17
198120352009A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.8

Citation

Dessen P

TRPC7 (transient receptor potential cation channel subfamily C member 7)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56042/trpc7