TRPM3 (transient receptor potential cation channel subfamily M member 3)

2015-02-01  

Identity

HGNC
LOCATION
9q21.12
LOCUSID
ALIAS
GON-2,LTRPC3,MLSN2
FUSION GENES

Other Information

Locus ID:

NCBI: 80036
MIM: 608961
HGNC: 17992
Ensembl: ENSG00000083067

Variants:

dbSNP: 80036
ClinVar: 80036
TCGA: ENSG00000083067
COSMIC: TRPM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083067ENST00000357533A2A3F7
ENSG00000083067ENST00000358082A2A3F4
ENSG00000083067ENST00000360823A2A3F4
ENSG00000083067ENST00000361823Q9HCF6
ENSG00000083067ENST00000377097H0Y3D4
ENSG00000083067ENST00000377101Q504Y1
ENSG00000083067ENST00000377105G5E9G1
ENSG00000083067ENST00000377110Q9HCF6
ENSG00000083067ENST00000377111Q9HCF6
ENSG00000083067ENST00000396280H7BYP1
ENSG00000083067ENST00000396283Q4VXD4
ENSG00000083067ENST00000396285A2A3F3
ENSG00000083067ENST00000396292E9PBI7
ENSG00000083067ENST00000408909G5E9G1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
158241112005Alternative splicing switches the divalent cation selectivity of TRPM3 channels.65
255177512014TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.51
155506782005Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected].46
203602462010Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.46
126728272003Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).44
204017282010TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells.29
208555652010Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.27
212782532011Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.26
261231952015Transient receptor potential melastatin 3 is a phosphoinositide-dependent ion channel.24

Citation

Dessen P

TRPM3 (transient receptor potential cation channel subfamily M member 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55070/trpm3