TRPV3 (transient receptor potential cation channel subfamily V member 3)

2016-10-01 Affiliation

Identity

HGNC

TRPV3

LOCATION

17p13.2

LOCUSID

162514

ALIAS

FNEPPK2,OLMS,OLMS1,VRL3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 162514
MIM: 607066
HGNC: 18084
Ensembl: ENSG00000167723

Variants:

dbSNP: 162514
ClinVar: 162514
TCGA: ENSG00000167723
COSMIC: TRPV3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167723	ENST00000301365	Q8NET8
ENSG00000167723	ENST00000381913	J3KPJ6
ENSG00000167723	ENST00000571139	I3L0L5
ENSG00000167723	ENST00000572519	Q8NET8
ENSG00000167723	ENST00000573539	I3L0L5
ENSG00000167723	ENST00000576742	Q8NET8
ENSG00000167723	ENST00000577016	I3L402
ENSG00000167723	ENST00000616411	A0A087X170

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Stimuli-sensing channels	REACTOME	R-HSA-2672351
TRP channels	REACTOME	R-HSA-3295583

References

Pubmed ID	Year	Title	Citations
12077604	2002	TRPV3 is a calcium-permeable temperature-sensitive cation channel.	237
12077606	2002	TRPV3 is a temperature-sensitive vanilloid receptor-like protein.	209
22405088	2012	Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome.	77
17521436	2007	Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy.	68
19864432	2010	Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.	61
18178557	2008	Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations.	44
20395302	2010	Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.	43
21321070	2011	Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.	35
22006988	2011	Hysteresis of gating underlines sensitization of TRPV3 channels.	28
18787888	2008	Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells.	25

Citation

Dessen P

TRPV3 (transient receptor potential cation channel subfamily V member 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56156/trpv3