TSC22D3 (TSC22 domain family member 3)

2010-02-01  

Identity

HGNC
TSC22D3
LOCATION
Xq22.3
LOCUSID
1831
ALIAS
DIP,DSIPI,GILZ,TSC-22R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1831
MIM: 300506
HGNC: 3051
Ensembl: ENSG00000157514

Variants:

dbSNP: 1831
ClinVar: 1831
TCGA: ENSG00000157514
COSMIC: TSC22D3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157514ENST00000315660Q99576
ENSG00000157514ENST00000372382Q5JRJ0
ENSG00000157514ENST00000372383Q99576
ENSG00000157514ENST00000372384Q99576
ENSG00000157514ENST00000372390Q5JRJ2
ENSG00000157514ENST00000372397Q99576
ENSG00000157514ENST00000480691D6RDZ9
ENSG00000157514ENST00000486554D6RD92
ENSG00000157514ENST00000502650D6RAX8
ENSG00000157514ENST00000502961D6R8Z7
ENSG00000157514ENST00000503515D6R9J1
ENSG00000157514ENST00000505965D6RDZ7
ENSG00000157514ENST00000506081Q99576
ENSG00000157514ENST00000506724D6RD37
ENSG00000157514ENST00000510887D6RBL1
ENSG00000157514ENST00000514426E7EWD5
ENSG00000157514ENST00000514897D6RCK9

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
123936032003Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.65
162168782005A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport.64
221375072012Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study.53
150312102004GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis.48
228328532012Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder.48
193807242009Epithelial sodium channel regulated by differential composition of a signaling complex.45
179568702007Differential activities of glucocorticoid-induced leucine zipper protein isoforms.37
215560282011Role of GILZ in immune regulation, glucocorticoid actions and rheumatoid arthritis.35
173561312007Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper.31
217507162011Identification of the chemokine CX3CL1 as a new regulator of malignant cell proliferation in epithelial ovarian cancer.21

Citation

Dessen P

TSC22D3 (TSC22 domain family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51354/tsc22d3