Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TSFM (Ts translation elongation factor, mitochondrial)

Identity

Alias_symbol (synonym)EF-Tsmt
EF-TS
Other aliasEFTS
EFTSMT
HGNC (Hugo) TSFM
LocusID (NCBI) 10102
Atlas_Id 54728
Location 12q14.1  [Link to chromosome band 12q14]
Location_base_pair Starts at 57782745 and ends at 57797587 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
METTL21B (12q14.1) / TSFM (12q14.1)TSFM (12q14.1) / IFNG (12q15)TSFM (12q14.1) / INHBE (12q13.3)
TSFM (12q14.1) / MARCH9 (12q14.1)TSFM (12q14.1) / NUP107 (12q15)TSFM (12q14.1) / TJAP1 (6p21.1)
TSFM 12q14.1 / MARCH9 12q14.1TSFM 12q14.1 / NUP107 12q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(6;12)(p21;q14) TSFM/TJAP1
t(12;12)(q13;q14) TSFM/INHBE
TSFM/MARCH9 (12q14)
t(12;12)(q14;q15) TSFM/IFNG
t(12;12)(q14;q15) TSFM/NUP107

External links

Nomenclature
HGNC (Hugo)TSFM   12367
Cards
Entrez_Gene (NCBI)TSFM  10102  Ts translation elongation factor, mitochondrial
AliasesEFTS; EFTSMT
GeneCards (Weizmann)TSFM
Ensembl hg19 (Hinxton)ENSG00000123297 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123297 [Gene_View]  ENSG00000123297 [Sequence]  chr12:57782745-57797587 [Contig_View]  TSFM [Vega]
ICGC DataPortalENSG00000123297
TCGA cBioPortalTSFM
AceView (NCBI)TSFM
Genatlas (Paris)TSFM
WikiGenes10102
SOURCE (Princeton)TSFM
Genetics Home Reference (NIH)TSFM
Genomic and cartography
GoldenPath hg38 (UCSC)TSFM  -     chr12:57782745-57797587 +  12q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSFM  -     12q14.1   [Description]    (hg19-Feb_2009)
GoldenPathTSFM - 12q14.1 [CytoView hg19]  TSFM - 12q14.1 [CytoView hg38]
ImmunoBaseENSG00000123297
Mapping of homologs : NCBITSFM [Mapview hg19]  TSFM [Mapview hg38]
OMIM604723   610505   
Gene and transcription
Genbank (Entrez)AF110399 AK295323 AK304621 AK308981 AK313453
RefSeq transcript (Entrez)NM_001172695 NM_001172696 NM_001172697 NM_005726
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TSFM
Cluster EST : UnigeneHs.632704 [ NCBI ]
CGAP (NCI)Hs.632704
Alternative Splicing GalleryENSG00000123297
Gene ExpressionTSFM [ NCBI-GEO ]   TSFM [ EBI - ARRAY_EXPRESS ]   TSFM [ SEEK ]   TSFM [ MEM ]
Gene Expression Viewer (FireBrowse)TSFM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10102
GTEX Portal (Tissue expression)TSFM
Human Protein AtlasENSG00000123297-TSFM [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43897   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43897  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43897
Splice isoforms : SwissVarP43897
PhosPhoSitePlusP43897
Domaine pattern : Prosite (Expaxy)EF_TS_1 (PS01126)    EF_TS_2 (PS01127)   
Domains : Interpro (EBI)EF-Ts_dimer_sf    Transl_elong_EFTs/EF1B    Transl_elong_EFTs/EF1B_dimer    Transl_elong_Ts_CS    UBA-like_sf   
Domain families : Pfam (Sanger)EF_TS (PF00889)   
Domain families : Pfam (NCBI)pfam00889   
Conserved Domain (NCBI)TSFM
DMDM Disease mutations10102
Blocks (Seattle)TSFM
PDB (RSDB)2CP9   
PDB Europe2CP9   
PDB (PDBSum)2CP9   
PDB (IMB)2CP9   
Structural Biology KnowledgeBase2CP9   
SCOP (Structural Classification of Proteins)2CP9   
CATH (Classification of proteins structures)2CP9   
SuperfamilyP43897
Human Protein Atlas [tissue]ENSG00000123297-TSFM [tissue]
Peptide AtlasP43897
HPRD05285
IPIIPI00021016   IPI00216260   IPI00910455   IPI01021816   IPI01022674   IPI00956590   IPI00916152   IPI00917718   IPI00916739   
Protein Interaction databases
DIP (DOE-UCLA)P43897
IntAct (EBI)P43897
FunCoupENSG00000123297
BioGRIDTSFM
STRING (EMBL)TSFM
ZODIACTSFM
Ontologies - Pathways
QuickGOP43897
Ontology : AmiGORNA binding  translation elongation factor activity  protein binding  nucleus  mitochondrion  mitochondrial matrix  translational elongation  regulation of DNA-templated transcription, elongation  mitochondrial translational elongation  regulation of mitochondrial translation  
Ontology : EGO-EBIRNA binding  translation elongation factor activity  protein binding  nucleus  mitochondrion  mitochondrial matrix  translational elongation  regulation of DNA-templated transcription, elongation  mitochondrial translational elongation  regulation of mitochondrial translation  
NDEx NetworkTSFM
Atlas of Cancer Signalling NetworkTSFM
Wikipedia pathwaysTSFM
Orthology - Evolution
OrthoDB10102
GeneTree (enSembl)ENSG00000123297
Phylogenetic Trees/Animal Genes : TreeFamTSFM
HOGENOMP43897
Homologs : HomoloGeneTSFM
Homology/Alignments : Family Browser (UCSC)TSFM
Gene fusions - Rearrangements
Fusion : MitelmanTSFM/IFNG [12q14.1/12q15]  
Fusion : MitelmanTSFM/INHBE [12q14.1/12q13.3]  [t(12;12)(q13;q14)]  
Fusion : MitelmanTSFM/MARCH9 [12q14.1/12q14.1]  [t(12;12)(q14;q14)]  
Fusion : MitelmanTSFM/NUP107 [12q14.1/12q15]  [t(12;12)(q14;q15)]  
Fusion : MitelmanTSFM/TJAP1 [12q14.1/6p21.1]  [t(6;12)(p21;q14)]  
Fusion PortalTSFM 12q14.1 MARCH9 12q14.1 LUAD
Fusion PortalTSFM 12q14.1 NUP107 12q15 GBM
Fusion : QuiverTSFM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSFM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSFM
dbVarTSFM
ClinVarTSFM
1000_GenomesTSFM 
Exome Variant ServerTSFM
ExAC (Exome Aggregation Consortium)ENSG00000123297
GNOMAD BrowserENSG00000123297
Varsome BrowserTSFM
Genetic variants : HAPMAP10102
Genomic Variants (DGV)TSFM [DGVbeta]
DECIPHERTSFM [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSFM 
Mutations
ICGC Data PortalTSFM 
TCGA Data PortalTSFM 
Broad Tumor PortalTSFM
OASIS PortalTSFM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSFM  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSFM
Mutations and Diseases : HGMDTSFM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TSFM
DgiDB (Drug Gene Interaction Database)TSFM
DoCM (Curated mutations)TSFM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSFM (select a term)
intoGenTSFM
Cancer3DTSFM(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604723    610505   
Orphanet17773   
DisGeNETTSFM
MedgenTSFM
Genetic Testing Registry TSFM
NextProtP43897 [Medical]
TSGene10102
GENETestsTSFM
Target ValidationTSFM
Huge Navigator TSFM [HugePedia]
snp3D : Map Gene to Disease10102
BioCentury BCIQTSFM
ClinGenTSFM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10102
Chemical/Pharm GKB GenePA37037
Clinical trialTSFM
Miscellaneous
canSAR (ICR)TSFM (select the gene name)
DataMed IndexTSFM
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSFM
EVEXTSFM
GoPubMedTSFM
iHOPTSFM
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:13:20 CET 2019
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.