TSLP (thymic stromal lymphopoietin)

2010-05-01  

Identity

HGNC
LOCATION
5q22.1
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 85480
MIM: 607003
HGNC: 30743
Ensembl: ENSG00000145777

Variants:

dbSNP: 85480
ClinVar: 85480
TCGA: ENSG00000145777
COSMIC: TSLP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145777ENST00000344895Q969D9
ENSG00000145777ENST00000379706Q969D9
ENSG00000145777ENST00000420978A0A0C4DG43

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630

References

Pubmed IDYearTitleCitations
120556252002Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.501
159443272005Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity.231
233639802013TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation.216
176359552007IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.191
216827362011The genetics of asthma and allergic disease: a 21st century perspective.159
202085342010Common variants at 5q22 associate with pediatric eosinophilic esophagitis.152
114186682001Human thymic stromal lymphopoietin preferentially stimulates myeloid cells.120
238727152013Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.118
172133202007Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB.103
195611092009Proteases induce production of thymic stromal lymphopoietin by airway epithelial cells through protease-activated receptor-2.102

Citation

Dessen P

TSLP (thymic stromal lymphopoietin)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51456/tslp