Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TSPAN12 (tetraspanin 12)

Identity

Alias_namesTM4SF12
transmembrane 4 superfamily member 12
Alias_symbol (synonym)NET-2
Other aliasEVR5
NET2
HGNC (Hugo) TSPAN12
LocusID (NCBI) 23554
Atlas_Id 52718
Location 7q31.31  [Link to chromosome band 7q31]
Location_base_pair Starts at 120787320 and ends at 120858123 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FANCL (2p16.1) / TSPAN12 (7q31.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TSPAN12   21641
Cards
Entrez_Gene (NCBI)TSPAN12  23554  tetraspanin 12
AliasesEVR5; NET-2; NET2; TM4SF12
GeneCards (Weizmann)TSPAN12
Ensembl hg19 (Hinxton)ENSG00000106025 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106025 [Gene_View]  ENSG00000106025 [Sequence]  chr7:120787320-120858123 [Contig_View]  TSPAN12 [Vega]
ICGC DataPortalENSG00000106025
TCGA cBioPortalTSPAN12
AceView (NCBI)TSPAN12
Genatlas (Paris)TSPAN12
WikiGenes23554
SOURCE (Princeton)TSPAN12
Genetics Home Reference (NIH)TSPAN12
Genomic and cartography
GoldenPath hg38 (UCSC)TSPAN12  -     chr7:120787320-120858123 -  7q31.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSPAN12  -     7q31.31   [Description]    (hg19-Feb_2009)
GoldenPathTSPAN12 - 7q31.31 [CytoView hg19]  TSPAN12 - 7q31.31 [CytoView hg38]
ImmunoBaseENSG00000106025
Mapping of homologs : NCBITSPAN12 [Mapview hg19]  TSPAN12 [Mapview hg38]
OMIM613138   613310   
Gene and transcription
Genbank (Entrez)AF124522 AK299247 AK307161 AK312239 AY358703
RefSeq transcript (Entrez)NM_012338
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TSPAN12
Cluster EST : UnigeneHs.16529 [ NCBI ]
CGAP (NCI)Hs.16529
Alternative Splicing GalleryENSG00000106025
Gene ExpressionTSPAN12 [ NCBI-GEO ]   TSPAN12 [ EBI - ARRAY_EXPRESS ]   TSPAN12 [ SEEK ]   TSPAN12 [ MEM ]
Gene Expression Viewer (FireBrowse)TSPAN12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23554
GTEX Portal (Tissue expression)TSPAN12
Human Protein AtlasENSG00000106025-TSPAN12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95859   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95859  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95859
Splice isoforms : SwissVarO95859
PhosPhoSitePlusO95859
Domaine pattern : Prosite (Expaxy)TM4_1 (PS00421)   
Domains : Interpro (EBI)Tetraspanin    Tetraspanin/Peripherin    Tetraspanin_CS    Tetraspanin_EC2_sf   
Domain families : Pfam (Sanger)Tetraspannin (PF00335)   
Domain families : Pfam (NCBI)pfam00335   
Conserved Domain (NCBI)TSPAN12
DMDM Disease mutations23554
Blocks (Seattle)TSPAN12
SuperfamilyO95859
Human Protein Atlas [tissue]ENSG00000106025-TSPAN12 [tissue]
Peptide AtlasO95859
HPRD15509
IPIIPI00000737   IPI00954561   IPI00925279   IPI00924651   IPI00924449   IPI00927754   IPI00927535   
Protein Interaction databases
DIP (DOE-UCLA)O95859
IntAct (EBI)O95859
FunCoupENSG00000106025
BioGRIDTSPAN12
STRING (EMBL)TSPAN12
ZODIACTSPAN12
Ontologies - Pathways
QuickGOO95859
Ontology : AmiGOangiogenesis  protein binding  integral component of plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  retina layer formation  membrane  integral component of membrane  Wnt signaling pathway  Wnt-activated receptor activity  regulation of angiogenesis  
Ontology : EGO-EBIangiogenesis  protein binding  integral component of plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  retina layer formation  membrane  integral component of membrane  Wnt signaling pathway  Wnt-activated receptor activity  regulation of angiogenesis  
NDEx NetworkTSPAN12
Atlas of Cancer Signalling NetworkTSPAN12
Wikipedia pathwaysTSPAN12
Orthology - Evolution
OrthoDB23554
GeneTree (enSembl)ENSG00000106025
Phylogenetic Trees/Animal Genes : TreeFamTSPAN12
HOGENOMO95859
Homologs : HomoloGeneTSPAN12
Homology/Alignments : Family Browser (UCSC)TSPAN12
Gene fusions - Rearrangements
Fusion : QuiverTSPAN12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSPAN12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSPAN12
dbVarTSPAN12
ClinVarTSPAN12
1000_GenomesTSPAN12 
Exome Variant ServerTSPAN12
ExAC (Exome Aggregation Consortium)ENSG00000106025
GNOMAD BrowserENSG00000106025
Varsome BrowserTSPAN12
Genetic variants : HAPMAP23554
Genomic Variants (DGV)TSPAN12 [DGVbeta]
DECIPHERTSPAN12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSPAN12 
Mutations
ICGC Data PortalTSPAN12 
TCGA Data PortalTSPAN12 
Broad Tumor PortalTSPAN12
OASIS PortalTSPAN12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSPAN12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSPAN12
Mutations and Diseases : HGMDTSPAN12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch TSPAN12
DgiDB (Drug Gene Interaction Database)TSPAN12
DoCM (Curated mutations)TSPAN12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TSPAN12 (select a term)
intoGenTSPAN12
Cancer3DTSPAN12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613138    613310   
Orphanet7036   
DisGeNETTSPAN12
MedgenTSPAN12
Genetic Testing Registry TSPAN12
NextProtO95859 [Medical]
TSGene23554
GENETestsTSPAN12
Target ValidationTSPAN12
Huge Navigator TSPAN12 [HugePedia]
snp3D : Map Gene to Disease23554
BioCentury BCIQTSPAN12
ClinGenTSPAN12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23554
Chemical/Pharm GKB GenePA134954047
Clinical trialTSPAN12
Miscellaneous
canSAR (ICR)TSPAN12 (select the gene name)
DataMed IndexTSPAN12
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTSPAN12
EVEXTSPAN12
GoPubMedTSPAN12
iHOPTSPAN12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:13:24 CET 2019
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