TSPAN2 (tetraspanin 2)

2014-08-01  

Identity

HGNC
TSPAN2
LOCATION
1p13.2
LOCUSID
10100
ALIAS
NET3,TSN2,TSPAN-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10100
MIM: 613133
HGNC: 20659
Ensembl: ENSG00000134198

Variants:

dbSNP: 10100
ClinVar: 10100
TCGA: ENSG00000134198
COSMIC: TSPAN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134198ENST00000369515B1AKP1
ENSG00000134198ENST00000369516O60636
ENSG00000134198ENST00000433172B1AKP2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
267086762016Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
232944582013Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine.19
291987232017DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation.18
247263682014TSPAN2 is involved in cell invasion and motility during lung cancer progression.15
272471272016Tetraspanin-2 promotes glucotoxic apoptosis by regulating the JNK/β-catenin signaling pathway in human pancreatic β cells.6
284084872017Tspan2: a tetraspanin protein involved in oligodendrogenesis and cancer metastasis.5

Citation

Dessen P

TSPAN2 (tetraspanin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54730/tspan2