TSPAN7 (tetraspanin 7)

2003-11-01 Affiliation

Identity

HGNC

TSPAN7

LOCATION

Xp11.4

LOCUSID

7102

ALIAS

A15,CCG-B7,CD231,DXS1692E,MRX58,MXS1,TALLA-1,TM4SF2,TM4SF2b

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7102
MIM: 300096
HGNC: 11854
Ensembl: ENSG00000156298

Variants:

dbSNP: 7102
ClinVar: 7102
TCGA: ENSG00000156298
COSMIC: TSPAN7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156298	ENST00000286824	B4DDG0
ENSG00000156298	ENST00000378482	P41732
ENSG00000156298	ENST00000471410	F8WF53
ENSG00000156298	ENST00000475216	F8WC96
ENSG00000156298	ENST00000480976	F8WF47

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Trafficking of GluR2-containing AMPA receptors	REACTOME	R-HSA-416993
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19736351	2009	Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.	151
20479760	2011	Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.	100
22445342	2012	The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking.	33
22213152	2012	CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases.	25
20630051	2010	Egress of HSV-1 capsid requires the interaction of VP26 and a cellular tetraspanin membrane protein.	9
20850477	2010	TL and CD8αα: Enigmatic partners in mucosal immunity.	9
25637218	2015	Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo.	9
20951001	2011	Wegener's granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin.	8
14735593	2004	Does the P172H mutation at the TM4SF2 gene cause X-linked mental retardation?	7
19339915	2009	Copy number variation analysis and sequencing of the X-linked mental retardation gene TSPAN7/TM4SF2 in patients with autism spectrum disorder.	4

Citation

Dessen P

TSPAN7 (tetraspanin 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42584/tspan7