Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84630
HGNC: 19140
Ensembl: ENSG00000146216
Variants:
dbSNP: 84630
ClinVar: 84630
TCGA: ENSG00000146216
COSMIC: TTBK1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000146216 | ENST00000259750 | Q5TCY1 |
| ENSG00000146216 | ENST00000304139 | X6R456 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37059819 | 2023 | Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. | 4 |
| 37059819 | 2023 | Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. | 4 |
| 34297427 | 2021 | The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro-degenerative hotspot. | 6 |
| 34297427 | 2021 | The structural, functional, and dynamic effect of Tau tubulin kinase1 upon a mutation: A neuro-degenerative hotspot. | 6 |
| 33228809 | 2020 | Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. | 4 |
| 33228809 | 2020 | Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. | 4 |
| 30556160 | 2019 | miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease. | 19 |
| 30556160 | 2019 | miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease. | 19 |
| 29409526 | 2018 | Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. | 41 |
| 29409526 | 2018 | Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration. | 41 |
| 24637750 | 2014 | The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. | 10 |
| 25473830 | 2014 | The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43. | 61 |
| 24637750 | 2014 | The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor. | 10 |
| 25473830 | 2014 | The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43. | 61 |
| 23088643 | 2013 | Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain. | 25 |
Citation
Dessen P
TTBK1 (tau tubulin kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43547/ttbk1
