Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TTC19 (tetratricopeptide repeat domain 19)

Identity

Alias_symbol (synonym)FLJ20343
MGC19520
Other alias2010204O13Rik
MC3DN2
HGNC (Hugo) TTC19
LocusID (NCBI) 54902
Atlas_Id 54732
Location 17p12  [Link to chromosome band 17p12]
Location_base_pair Starts at 15999380 and ends at 16029409 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM83G (17p11.2) / TTC19 (17p12)FLOT1 (6p21.33) / TTC19 (17p12)PODXL (7q32.3) / TTC19 (17p12)
TTC19 (17p12) / ATPAF2 (17p11.2)TTC19 (17p12) / NCOR1 (17p12)TTC19 (17p12) / TOM1L2 (17p11.2)
TTC19 (17p12) / TTC19 (17p12)FAM83G 17p11.2 / TTC19 17p12TTC19 17p12 / TOM1L2 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Lung: Translocations in Adenocarcinoma
t(17;17)(p11;p12) FAM83G/TTC19
t(17;17)(p11;p12) TTC19/TOM1L2
t(17;17)(p12;p11) TTC19/ATPAF2

External links

Nomenclature
HGNC (Hugo)TTC19   26006
Cards
Entrez_Gene (NCBI)TTC19  54902  tetratricopeptide repeat domain 19
Aliases2010204O13Rik; MC3DN2
GeneCards (Weizmann)TTC19
Ensembl hg19 (Hinxton)ENSG00000011295 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011295 [Gene_View]  ENSG00000011295 [Sequence]  chr17:15999380-16029409 [Contig_View]  TTC19 [Vega]
ICGC DataPortalENSG00000011295
TCGA cBioPortalTTC19
AceView (NCBI)TTC19
Genatlas (Paris)TTC19
WikiGenes54902
SOURCE (Princeton)TTC19
Genetics Home Reference (NIH)TTC19
Genomic and cartography
GoldenPath hg38 (UCSC)TTC19  -     chr17:15999380-16029409 +  17p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC19  -     17p12   [Description]    (hg19-Feb_2009)
GoldenPathTTC19 - 17p12 [CytoView hg19]  TTC19 - 17p12 [CytoView hg38]
ImmunoBaseENSG00000011295
Mapping of homologs : NCBITTC19 [Mapview hg19]  TTC19 [Mapview hg38]
OMIM613814   615157   
Gene and transcription
Genbank (Entrez)AK000350 AK025958 AK055780 AK056878 AK094819
RefSeq transcript (Entrez)NM_001271420 NM_017775
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTC19
Cluster EST : UnigeneHs.462316 [ NCBI ]
CGAP (NCI)Hs.462316
Alternative Splicing GalleryENSG00000011295
Gene ExpressionTTC19 [ NCBI-GEO ]   TTC19 [ EBI - ARRAY_EXPRESS ]   TTC19 [ SEEK ]   TTC19 [ MEM ]
Gene Expression Viewer (FireBrowse)TTC19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54902
GTEX Portal (Tissue expression)TTC19
Human Protein AtlasENSG00000011295-TTC19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6DKK2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6DKK2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6DKK2
Splice isoforms : SwissVarQ6DKK2
PhosPhoSitePlusQ6DKK2
Domaine pattern : Prosite (Expaxy)TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TTC19
DMDM Disease mutations54902
Blocks (Seattle)TTC19
SuperfamilyQ6DKK2
Human Protein Atlas [tissue]ENSG00000011295-TTC19 [tissue]
Peptide AtlasQ6DKK2
HPRD07899
IPIIPI01011392   IPI00798151   
Protein Interaction databases
DIP (DOE-UCLA)Q6DKK2
IntAct (EBI)Q6DKK2
FunCoupENSG00000011295
BioGRIDTTC19
STRING (EMBL)TTC19
ZODIACTTC19
Ontologies - Pathways
QuickGOQ6DKK2
Ontology : AmiGOmitotic cytokinesis  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  centrosome  midbody  mitochondrial respiratory chain complex III assembly  mitochondrial respiratory chain complex III assembly  oxidation-reduction process  respiratory chain  
Ontology : EGO-EBImitotic cytokinesis  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial inner membrane  centrosome  midbody  mitochondrial respiratory chain complex III assembly  mitochondrial respiratory chain complex III assembly  oxidation-reduction process  respiratory chain  
NDEx NetworkTTC19
Atlas of Cancer Signalling NetworkTTC19
Wikipedia pathwaysTTC19
Orthology - Evolution
OrthoDB54902
GeneTree (enSembl)ENSG00000011295
Phylogenetic Trees/Animal Genes : TreeFamTTC19
HOGENOMQ6DKK2
Homologs : HomoloGeneTTC19
Homology/Alignments : Family Browser (UCSC)TTC19
Gene fusions - Rearrangements
Fusion : MitelmanFAM83G/TTC19 [17p11.2/17p12]  [t(17;17)(p11;p12)]  
Fusion : MitelmanTTC19/ATPAF2 [17p12/17p11.2]  [t(17;17)(p11;p12)]  
Fusion : MitelmanTTC19/TOM1L2 [17p12/17p11.2]  [t(17;17)(p11;p12)]  
Fusion PortalFAM83G 17p11.2 TTC19 17p12 BRCA
Fusion PortalTTC19 17p12 TOM1L2 17p11.2 BRCA
Fusion : QuiverTTC19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC19
dbVarTTC19
ClinVarTTC19
1000_GenomesTTC19 
Exome Variant ServerTTC19
ExAC (Exome Aggregation Consortium)ENSG00000011295
GNOMAD BrowserENSG00000011295
Varsome BrowserTTC19
Genetic variants : HAPMAP54902
Genomic Variants (DGV)TTC19 [DGVbeta]
DECIPHERTTC19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC19 
Mutations
ICGC Data PortalTTC19 
TCGA Data PortalTTC19 
Broad Tumor PortalTTC19
OASIS PortalTTC19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC19  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTC19
Mutations and Diseases : HGMDTTC19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TTC19
DgiDB (Drug Gene Interaction Database)TTC19
DoCM (Curated mutations)TTC19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTC19 (select a term)
intoGenTTC19
Cancer3DTTC19(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613814    615157   
Orphanet3378   
DisGeNETTTC19
MedgenTTC19
Genetic Testing Registry TTC19
NextProtQ6DKK2 [Medical]
TSGene54902
GENETestsTTC19
Target ValidationTTC19
Huge Navigator TTC19 [HugePedia]
snp3D : Map Gene to Disease54902
BioCentury BCIQTTC19
ClinGenTTC19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54902
Chemical/Pharm GKB GenePA134922384
Clinical trialTTC19
Miscellaneous
canSAR (ICR)TTC19 (select the gene name)
DataMed IndexTTC19
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTC19
EVEXTTC19
GoPubMedTTC19
iHOPTTC19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:13:30 CET 2019
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