Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TTC3 (tetratricopeptide repeat domain 3)

Identity

Alias_symbol (synonym)TPRD
TPRDI
DCRR1
TPRDII
TPRDIII
RNF105
Other alias
HGNC (Hugo) TTC3
LocusID (NCBI) 7267
Atlas_Id 75282
Location 21q22.13  [Link to chromosome band 21q22]
Location_base_pair Starts at 37073184 and ends at 37203118 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC71 (3p21.31) / TTC3 (21q22.13)CENPP (9q22.31) / TTC3 (21q22.13)DYRK1A (21q22.13) / TTC3 (21q22.13)
SMARCB1 (22q11.23) / TTC3 (21q22.13)TTC3 (21q22.13) / BRWD1 (21q22.2)TTC3 (21q22.13) / TTC3 (21q22.13)
TTC3 (21q22.13) / UBR5 (8q22.3)WHSC1L1 (8p11.23) / TTC3 (21q22.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TTC3   12393
Cards
Entrez_Gene (NCBI)TTC3  7267  tetratricopeptide repeat domain 3
AliasesDCRR1; RNF105; TPRDIII
GeneCards (Weizmann)TTC3
Ensembl hg19 (Hinxton)ENSG00000182670 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182670 [Gene_View]  ENSG00000182670 [Sequence]  chr21:37073184-37203118 [Contig_View]  TTC3 [Vega]
ICGC DataPortalENSG00000182670
TCGA cBioPortalTTC3
AceView (NCBI)TTC3
Genatlas (Paris)TTC3
WikiGenes7267
SOURCE (Princeton)TTC3
Genetics Home Reference (NIH)TTC3
Genomic and cartography
GoldenPath hg38 (UCSC)TTC3  -     chr21:37073184-37203118 +  21q22.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC3  -     21q22.13   [Description]    (hg19-Feb_2009)
GoldenPathTTC3 - 21q22.13 [CytoView hg19]  TTC3 - 21q22.13 [CytoView hg38]
ImmunoBaseENSG00000182670
Mapping of homologs : NCBITTC3 [Mapview hg19]  TTC3 [Mapview hg38]
OMIM602259   
Gene and transcription
Genbank (Entrez)AA482675 AI066542 AI393300 AI745113 AJ001866
RefSeq transcript (Entrez)NM_001001894 NM_001320703 NM_001320704 NM_001330681 NM_001330682 NM_001330683 NM_001353936 NM_001353937 NM_001353938 NM_003316
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTC3
Cluster EST : UnigeneHs.368214 [ NCBI ]
CGAP (NCI)Hs.368214
Alternative Splicing GalleryENSG00000182670
Gene ExpressionTTC3 [ NCBI-GEO ]   TTC3 [ EBI - ARRAY_EXPRESS ]   TTC3 [ SEEK ]   TTC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TTC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7267
GTEX Portal (Tissue expression)TTC3
Human Protein AtlasENSG00000182670-TTC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53804   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53804  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53804
Splice isoforms : SwissVarP53804
PhosPhoSitePlusP53804
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  TPR (SM00028)  
Conserved Domain (NCBI)TTC3
DMDM Disease mutations7267
Blocks (Seattle)TTC3
SuperfamilyP53804
Human Protein Atlas [tissue]ENSG00000182670-TTC3 [tissue]
Peptide AtlasP53804
HPRD03773
IPIIPI00023977   IPI00215848   IPI00215849   IPI00922045   IPI00790123   IPI00793407   IPI00791903   IPI00794467   IPI00792735   IPI00795884   IPI00794134   
Protein Interaction databases
DIP (DOE-UCLA)P53804
IntAct (EBI)P53804
FunCoupENSG00000182670
BioGRIDTTC3
STRING (EMBL)TTC3
ZODIACTTC3
Ontologies - Pathways
QuickGOP53804
Ontology : AmiGOubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleolus  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  metal ion binding  protein K48-linked ubiquitination  
Ontology : EGO-EBIubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  nucleolus  cytosol  ubiquitin-dependent protein catabolic process  ubiquitin-dependent protein catabolic process  metal ion binding  protein K48-linked ubiquitination  
NDEx NetworkTTC3
Atlas of Cancer Signalling NetworkTTC3
Wikipedia pathwaysTTC3
Orthology - Evolution
OrthoDB7267
GeneTree (enSembl)ENSG00000182670
Phylogenetic Trees/Animal Genes : TreeFamTTC3
HOGENOMP53804
Homologs : HomoloGeneTTC3
Homology/Alignments : Family Browser (UCSC)TTC3
Gene fusions - Rearrangements
Fusion : QuiverTTC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC3
dbVarTTC3
ClinVarTTC3
1000_GenomesTTC3 
Exome Variant ServerTTC3
ExAC (Exome Aggregation Consortium)ENSG00000182670
GNOMAD BrowserENSG00000182670
Varsome BrowserTTC3
Genetic variants : HAPMAP7267
Genomic Variants (DGV)TTC3 [DGVbeta]
DECIPHERTTC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC3 
Mutations
ICGC Data PortalTTC3 
TCGA Data PortalTTC3 
Broad Tumor PortalTTC3
OASIS PortalTTC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTC3
Mutations and Diseases : HGMDTTC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTC3
DgiDB (Drug Gene Interaction Database)TTC3
DoCM (Curated mutations)TTC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTC3 (select a term)
intoGenTTC3
Cancer3DTTC3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602259   
Orphanet
DisGeNETTTC3
MedgenTTC3
Genetic Testing Registry TTC3
NextProtP53804 [Medical]
TSGene7267
GENETestsTTC3
Target ValidationTTC3
Huge Navigator TTC3 [HugePedia]
snp3D : Map Gene to Disease7267
BioCentury BCIQTTC3
ClinGenTTC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7267
Chemical/Pharm GKB GenePA37058
Clinical trialTTC3
Miscellaneous
canSAR (ICR)TTC3 (select the gene name)
DataMed IndexTTC3
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTC3
EVEXTTC3
GoPubMedTTC3
iHOPTTC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 16:11:44 CEST 2019
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