TTC3 (tetratricopeptide repeat domain 3)

2014-11-01  

Identity

HGNC
LOCATION
21q22.13
LOCUSID
ALIAS
DCRR1,RNF105,TPRDIII
FUSION GENES

Other Information

Locus ID:

NCBI: 7267
MIM: 602259
HGNC: 12393
Ensembl: ENSG00000182670

Variants:

dbSNP: 7267
ClinVar: 7267
TCGA: ENSG00000182670
COSMIC: TTC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182670ENST00000354749P53804
ENSG00000182670ENST00000355666P53804
ENSG00000182670ENST00000399010A8MT23
ENSG00000182670ENST00000399017P53804
ENSG00000182670ENST00000411496H7BZ57
ENSG00000182670ENST00000414818H7C3Z1
ENSG00000182670ENST00000418766E9PMP8
ENSG00000182670ENST00000428693H7C097
ENSG00000182670ENST00000438055E9PCE7
ENSG00000182670ENST00000450533E9PMS7
ENSG00000182670ENST00000540756B4DSZ9

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
200599502009The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt.51
174887802007The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.20
275864452016An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome.19
306968092019TTC3 contributes to TGF-β1-induced epithelial-mesenchymal transition and myofibroblast differentiation, potentially through SMURF2 ubiquitylation and degradation.6

Citation

Dessen P

TTC3 (tetratricopeptide repeat domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75282/ttc3