TTF1 (transcription termination factor 1)

2007-02-01  

Identity

HGNC
LOCATION
9q34.13
LOCUSID
ALIAS
TTF-1,TTF-I
FUSION GENES

Other Information

Locus ID:

NCBI: 7270
MIM: 600777
HGNC: 12397
Ensembl: ENSG00000125482

Variants:

dbSNP: 7270
ClinVar: 7270
TCGA: ENSG00000125482
COSMIC: TTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125482ENST00000334270Q15361
ENSG00000125482ENST00000334270A0A024R8C1
ENSG00000125482ENST00000612514A0A087WY09

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Metabolism of proteinsREACTOMER-HSA-392499
DiseaseREACTOMER-HSA-1643685
Diseases of metabolismREACTOMER-HSA-5668914
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
Diseases associated with surfactant metabolismREACTOMER-HSA-5687613
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)REACTOMER-HSA-5688031
Surfactant metabolismREACTOMER-HSA-5683826
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205134292010The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.41
291684592017p40 & thyroid transcription factor-1 immunohistochemistry: A useful panel to characterize non-small cell lung carcinoma-not otherwise specified (NSCLC-NOS) category.8
260361882015Overexpression of Transcription Termination Factor 1 is Associated with a Poor Prognosis in Patients with Colorectal Cancer.7
296586092018Survivin knockdown induces senescence in TTF‑1-expressing, KRAS-mutant lung adenocarcinomas.3
268238912015KRAS mutation-positive bronchial surface epithelium (BSE)-type lung adenocarcinoma with strong expression of TTF-1: a case providing a further insight as for the role of TTF-1 in the oncogenesis.1
282468832017Novel linkage disequilibrium clustering algorithm identifies new lupus genes on meta-analysis of GWAS datasets.1
291041092018Aberrant expression of thyroid transcription factor-1 in schwannomas.1
301942072018TTF-1 Expression Predicts the Merit of Additional Antiangiogenic Treatment in Non-squamous Non-small Cell Lung Cancer.1
295550142018Investigation of functional roles of transcription termination factor-1 (TTF-I) in HIV-1 replication.0
303487182018Prognostic Value of Thyroid Transcription Factor-1 Expression in Patients with Advanced Lung Adenocarcinoma.0

Citation

Dessen P

TTF1 (transcription termination factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46184/ttf1