TTYH2 (tweety family member 2)

2004-11-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
C17orf29
FUSION GENES

Other Information

Locus ID:

NCBI: 94015
MIM: 608855
HGNC: 13877
Ensembl: ENSG00000141540

Variants:

dbSNP: 94015
ClinVar: 94015
TCGA: ENSG00000141540
COSMIC: TTYH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141540ENST00000269346Q9BSA4
ENSG00000141540ENST00000441391Q9BSA4
ENSG00000141540ENST00000526858J3KSH7
ENSG00000141540ENST00000528128J3KRY9
ENSG00000141540ENST00000529107B4DKD1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

References

Pubmed IDYearTitleCitations
115971452001TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma.10
185775132008The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels.9
175691412007TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation.8
182608272008N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2).7
306701462019Surface expression of TTYH2 is attenuated by direct interaction with β-COP.2
312307492019Upregulated TTYH2 expression is critical for the invasion and migration of U2OS human osteosarcoma cell lines.1

Citation

Dessen P

TTYH2 (tweety family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-11-01

Online version: http://atlasgeneticsoncology.org/gene/42954/ttyh2