TUBG1 (tubulin gamma 1)

2009-06-01 Affiliation

Identity

HGNC

TUBG1

LOCATION

17q21.2

LOCUSID

7283

ALIAS

CDCBM4,GCP-1,TUBG,TUBGCP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7283
MIM: 191135
HGNC: 12417
Ensembl: ENSG00000131462

Variants:

dbSNP: 7283
ClinVar: 7283
TCGA: ENSG00000131462
COSMIC: TUBG1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000131462	ENST00000251413	P23258
ENSG00000131462	ENST00000589688	K7EKE5
ENSG00000131462	ENST00000591509	K7EIS0

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Anchoring of the basal body to the plasma membrane	REACTOME	R-HSA-5620912
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Centrosome maturation	REACTOME	R-HSA-380287
Recruitment of mitotic centrosome proteins and complexes	REACTOME	R-HSA-380270
Recruitment of NuMA to mitotic centrosomes	REACTOME	R-HSA-380320
Loss of proteins required for interphase microtubule organization from the centrosome	REACTOME	R-HSA-380284
Loss of Nlp from mitotic centrosomes	REACTOME	R-HSA-380259
AURKA Activation by TPX2	REACTOME	R-HSA-8854518

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19543530	2009	Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components.	84
15917813	2005	Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.	60
19509060	2009	Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the gammaTuRC to the centrosome.	34
19648910	2009	SADB phosphorylation of gamma-tubulin regulates centrosome duplication.	29
22818914	2012	Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of γ-tubulin recruitment to the mitotic centrosome.	28
18316369	2008	GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5.	24
17406983	2007	Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.	21
20508983	2011	Centrosome-related genes, genetic variation, and risk of breast cancer.	16
21795687	2011	CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.	15
20224777	2010	A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.	13

Citation

Dessen P

TUBG1 (tubulin gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50980/tubg1