TUBGCP3 (tubulin gamma complex associated protein 3)

2014-08-01  

Identity

HGNC
TUBGCP3
LOCATION
13q34
LOCUSID
10426
ALIAS
104p,ALP6,GCP3,Grip104,SPBC98,Spc98,Spc98p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10426
MIM: 617818
HGNC: 18598
Ensembl: ENSG00000126216

Variants:

dbSNP: 10426
ClinVar: 10426
TCGA: ENSG00000126216
COSMIC: TUBGCP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126216ENST00000261965Q96CW5
ENSG00000126216ENST00000375669Q96CW5
ENSG00000126216ENST00000464139A0A087WU06
ENSG00000126216ENST00000611152A0A087WZV5
ENSG00000126216ENST00000649778A0A3B3ITE3

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208586832010Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.170
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
192994672009Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.10
260794482015Overexpression and Nucleolar Localization of γ-Tubulin Small Complex Proteins GCP2 and GCP3 in Glioblastoma.10
238869392013Functional replacement of fission yeast γ-tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3.5
288510272017NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex.3

Citation

Dessen P

TUBGCP3 (tubulin gamma complex associated protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54738/tubgcp3