TUSC2 (tumor suppressor 2, mitochondrial calcium regulator)

2003-02-01  

Identity

HGNC
TUSC2
LOCATION
3p21.31
LOCUSID
11334
ALIAS
C3orf11,FUS1,PAP,PDAP2

Other Information

Locus ID:

NCBI: 11334
MIM: 607052
HGNC: 17034
Ensembl: ENSG00000114383

Variants:

dbSNP: 11334
ClinVar: 11334
TCGA: ENSG00000114383
COSMIC: TUSC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114383ENST00000232496O75896
ENSG00000114383ENST00000417867G3V0I0
ENSG00000114383ENST00000421918F2Z2A9
ENSG00000114383ENST00000454201F2Z2A9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
180773752007MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression.210
196716782009miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1.99
243944982014The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs.47
181722502008Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer.38
151263272004Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells.27
115934362001Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells.24
198528442009Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effects.18
263677732015Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression.15
241469572013The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner.10
260530202015Exogenous Restoration of TUSC2 Expression Induces Responsiveness to Erlotinib in Wildtype Epidermal Growth Factor Receptor (EGFR) Lung Cancer Cells through Context Specific Pathways Resulting in Enhanced Therapeutic Efficacy.8

Citation

Dessen P

TUSC2 (tumor suppressor 2, mitochondrial calcium regulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42731/tusc2