TWSG1 (twisted gastrulation BMP signaling modulator 1)

2014-08-01  

Identity

HGNC
TWSG1
LOCATION
18p11.22
LOCUSID
57045
ALIAS
TSG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57045
MIM: 605049
HGNC: 12429
Ensembl: ENSG00000128791

Variants:

dbSNP: 57045
ClinVar: 57045
TCGA: ENSG00000128791
COSMIC: TWSG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128791ENST00000262120Q9GZX9
ENSG00000128791ENST00000581641J3QS03
ENSG00000128791ENST00000583147Q9GZX9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194148612009Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells.122
236410682013Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation.12
171643482007Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes.7
265178842015The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity.5
212277282011Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly.4
268294662016Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway.3
297569962018TWSG1 Is a Novel Tumor Suppressor in Gastric Cancer.2
301256192019Internal cleavage and synergy with twisted gastrulation enhance BMP inhibition by BMPER.1

Citation

Dessen P

TWSG1 (twisted gastrulation BMP signaling modulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54739/twsg1