TXNDC12 (thioredoxin domain containing 12)

2016-04-01  

Identity

HGNC
TXNDC12
LOCATION
1p32.3
LOCUSID
51060
ALIAS
AG1,AGR1,ERP16,ERP18,ERP19,PDIA16,TLP19,hAG-1,hTLP19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51060
MIM: 609448
HGNC: 24626
Ensembl: ENSG00000117862

Variants:

dbSNP: 51060
ClinVar: 51060
TCGA: ENSG00000117862
COSMIC: TXNDC12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117862ENST00000371626O95881
ENSG00000117862ENST00000472624V9GYV4
ENSG00000117862ENST00000610127V9GY50

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480

References

Pubmed IDYearTitleCitations
198875852009Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins.75
127612122003Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member.24
193612262009Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase .10
186282062008ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress.9
313686012019ERp18 regulates activation of ATF6α during unfolded protein response.9
259404402015ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion.5

Citation

Dessen P

TXNDC12 (thioredoxin domain containing 12)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55702/txndc12