Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TXNDC16 (thioredoxin domain containing 16)

Identity

Alias_namesKIAA1344
KIAA1344
Other aliasERp90
HGNC (Hugo) TXNDC16
LocusID (NCBI) 57544
Atlas_Id 52894
Location 14q22.1  [Link to chromosome band 14q22]
Location_base_pair Starts at 52430590 and ends at 52552583 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AGPAT5 (8p23.1) / TXNDC16 (14q22.1)KCTD3 (1q41) / TXNDC16 (14q22.1)SUSD6 (14q24.1) / TXNDC16 (14q22.1)
TXNDC16 (14q22.1) / GPR137C (14q22.1)XPO6 (16p11.2) / TXNDC16 (14q22.1)KIAA0247 TXNDC16 14q22.1
TXNDC16 14q22.1 / GPR137C 14q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Small Cell Carcinoma
t(1;14)(q41;q22) KCTD3/TXNDC16
t(8;14)(p23;q22) AGPAT5/TXNDC16
TXNDC16/GPR137C (14q22)
t(14;14)(q22;q24) SUSD6/TXNDC16

External links

Nomenclature
HGNC (Hugo)TXNDC16   19965
Cards
Entrez_Gene (NCBI)TXNDC16  57544  thioredoxin domain containing 16
AliasesERp90; KIAA1344
GeneCards (Weizmann)TXNDC16
Ensembl hg19 (Hinxton)ENSG00000087301 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087301 [Gene_View]  ENSG00000087301 [Sequence]  chr14:52430590-52552583 [Contig_View]  TXNDC16 [Vega]
ICGC DataPortalENSG00000087301
TCGA cBioPortalTXNDC16
AceView (NCBI)TXNDC16
Genatlas (Paris)TXNDC16
WikiGenes57544
SOURCE (Princeton)TXNDC16
Genetics Home Reference (NIH)TXNDC16
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC16  -     chr14:52430590-52552583 -  14q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC16  -     14q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTXNDC16 - 14q22.1 [CytoView hg19]  TXNDC16 - 14q22.1 [CytoView hg38]
ImmunoBaseENSG00000087301
Mapping of homologs : NCBITXNDC16 [Mapview hg19]  TXNDC16 [Mapview hg38]
OMIM616179   
Gene and transcription
Genbank (Entrez)AB037765 AK022563 AK097748 BC137081 BC137082
RefSeq transcript (Entrez)NM_001160047 NM_020784
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TXNDC16
Cluster EST : UnigeneHs.532609 [ NCBI ]
CGAP (NCI)Hs.532609
Alternative Splicing GalleryENSG00000087301
Gene ExpressionTXNDC16 [ NCBI-GEO ]   TXNDC16 [ EBI - ARRAY_EXPRESS ]   TXNDC16 [ SEEK ]   TXNDC16 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57544
GTEX Portal (Tissue expression)TXNDC16
Human Protein AtlasENSG00000087301-TXNDC16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2K2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2K2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2K2
Splice isoforms : SwissVarQ9P2K2
PhosPhoSitePlusQ9P2K2
Domains : Interpro (EBI)Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC16
DMDM Disease mutations57544
Blocks (Seattle)TXNDC16
SuperfamilyQ9P2K2
Human Protein Atlas [tissue]ENSG00000087301-TXNDC16 [tissue]
Peptide AtlasQ9P2K2
HPRD11140
IPIIPI00642204   IPI01025462   IPI01025784   IPI00930187   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2K2
IntAct (EBI)Q9P2K2
FunCoupENSG00000087301
BioGRIDTXNDC16
STRING (EMBL)TXNDC16
ZODIACTXNDC16
Ontologies - Pathways
QuickGOQ9P2K2
Ontology : AmiGOprotein binding  endoplasmic reticulum lumen  biological_process  cell redox homeostasis  extracellular exosome  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum lumen  biological_process  cell redox homeostasis  extracellular exosome  
NDEx NetworkTXNDC16
Atlas of Cancer Signalling NetworkTXNDC16
Wikipedia pathwaysTXNDC16
Orthology - Evolution
OrthoDB57544
GeneTree (enSembl)ENSG00000087301
Phylogenetic Trees/Animal Genes : TreeFamTXNDC16
HOGENOMQ9P2K2
Homologs : HomoloGeneTXNDC16
Homology/Alignments : Family Browser (UCSC)TXNDC16
Gene fusions - Rearrangements
Fusion : MitelmanAGPAT5/TXNDC16 [8p23.1/14q22.1]  [t(8;14)(p23;q22)]  
Fusion : MitelmanKCTD3/TXNDC16 [1q41/14q22.1]  [t(1;14)(q41;q22)]  
Fusion : MitelmanSUSD6/TXNDC16 [14q24.1/14q22.1]  [t(14;14)(q22;q24)]  
Fusion : MitelmanTXNDC16/GPR137C [14q22.1/14q22.1]  [t(14;14)(q22;q22)]  
Fusion PortalKIAA0247 TXNDC16 14q22.1 LUAD
Fusion PortalTXNDC16 14q22.1 GPR137C 14q22.1 BRCA
Fusion : QuiverTXNDC16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC16
dbVarTXNDC16
ClinVarTXNDC16
1000_GenomesTXNDC16 
Exome Variant ServerTXNDC16
ExAC (Exome Aggregation Consortium)ENSG00000087301
GNOMAD BrowserENSG00000087301
Varsome BrowserTXNDC16
Genetic variants : HAPMAP57544
Genomic Variants (DGV)TXNDC16 [DGVbeta]
DECIPHERTXNDC16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC16 
Mutations
ICGC Data PortalTXNDC16 
TCGA Data PortalTXNDC16 
Broad Tumor PortalTXNDC16
OASIS PortalTXNDC16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC16  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTXNDC16
Mutations and Diseases : HGMDTXNDC16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXNDC16
DgiDB (Drug Gene Interaction Database)TXNDC16
DoCM (Curated mutations)TXNDC16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC16 (select a term)
intoGenTXNDC16
Cancer3DTXNDC16(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616179   
Orphanet
DisGeNETTXNDC16
MedgenTXNDC16
Genetic Testing Registry TXNDC16
NextProtQ9P2K2 [Medical]
TSGene57544
GENETestsTXNDC16
Target ValidationTXNDC16
Huge Navigator TXNDC16 [HugePedia]
snp3D : Map Gene to Disease57544
BioCentury BCIQTXNDC16
ClinGenTXNDC16
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57544
Chemical/Pharm GKB GenePA162407488
Clinical trialTXNDC16
Miscellaneous
canSAR (ICR)TXNDC16 (select the gene name)
DataMed IndexTXNDC16
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNDC16
EVEXTXNDC16
GoPubMedTXNDC16
iHOPTXNDC16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:13:44 CET 2019
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