Identity
HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
GCCD5,SELZ,TR,TR-BETA,TR3,TRXR2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10587
MIM: 606448
HGNC: 18155
Ensembl: ENSG00000184470
Variants:
dbSNP: 10587
ClinVar: 10587
TCGA: ENSG00000184470
COSMIC: TXNRD2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | ClinicalAnnotation | associated | PD | ||
| PA445043 | Opioid-Related Disorders | Disease | ClinicalAnnotation | associated | PD | 32407152 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | ||
| PA450401 | methadone | Chemical | ClinicalAnnotation | associated | PD | 32407152 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34461764 | 2022 | Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma. | 1 |
| 35416905 | 2022 | TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondenceReply to "TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondence"Primary open-angle glaucomaGenome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucomaGenome-wide association study of primary open-angle glaucoma in continental and admixed African populations. | 0 |
| 34461764 | 2022 | Association analysis of variants rs35934224 in TXNRD2 and rs6478746 in LMX1B in primary angle-closure and pseudoexfoliation glaucoma. | 1 |
| 35416905 | 2022 | TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondenceReply to "TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondence"Primary open-angle glaucomaGenome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucomaGenome-wide association study of primary open-angle glaucoma in continental and admixed African populations. | 0 |
| 33332541 | 2021 | miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2. | 7 |
| 34431894 | 2021 | TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. | 1 |
| 33332541 | 2021 | miR-195-5p exerts tumor-suppressive functions in human lung cancer cells through targeting TrxR2. | 7 |
| 34431894 | 2021 | TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. | 1 |
| 29653292 | 2019 | The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. | 6 |
| 29653292 | 2019 | The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease. | 6 |
| 29327078 | 2018 | The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker? | 41 |
| 29327078 | 2018 | The role of the thioredoxin/thioredoxin reductase system in the metabolic syndrome: towards a possible prognostic marker? | 41 |
| 27866984 | 2017 | p53R2 regulates thioredoxin reductase activity through interaction with TrxR2. | 5 |
| 28414076 | 2017 | Inhibition of TrxR2 suppressed NSCLC cell proliferation, metabolism and induced cell apoptosis through decreasing antioxidant activity. | 8 |
| 27866984 | 2017 | p53R2 regulates thioredoxin reductase activity through interaction with TrxR2. | 5 |
Citation
Dessen P
TXNRD2 (thioredoxin reductase 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/42736/txnrd2
