TXNRD2 (thioredoxin reductase 2)

2003-05-01 Affiliation

Identity

HGNC

TXNRD2

LOCATION

22q11.21

LOCUSID

10587

ALIAS

GCCD5,SELZ,TR,TR-BETA,TR3,TRXR2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10587
MIM: 606448
HGNC: 18155
Ensembl: ENSG00000184470

Variants:

dbSNP: 10587
ClinVar: 10587
TCGA: ENSG00000184470
COSMIC: TXNRD2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184470	ENST00000334363	E7EWK1
ENSG00000184470	ENST00000400518	A0A182DWF2
ENSG00000184470	ENST00000400519	A0A182DWF3
ENSG00000184470	ENST00000400521	Q9NNW7
ENSG00000184470	ENST00000400525	D3YTF8
ENSG00000184470	ENST00000462330	A0A096LPH4
ENSG00000184470	ENST00000462843	A0A096LP96
ENSG00000184470	ENST00000474308	A0A096LPK7
ENSG00000184470	ENST00000475995	A0A096LNY7
ENSG00000184470	ENST00000485358	A0A096LPB7
ENSG00000184470	ENST00000491939	A0A096LPD9
ENSG00000184470	ENST00000634537	A0A0U1RQX0

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pyrimidine metabolism	KEGG	ko00240
Selenocompound metabolism	KEGG	ko00450
Pyrimidine metabolism	KEGG	hsa00240
Selenocompound metabolism	KEGG	hsa00450
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation	associated	PD
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated	PD	32407152
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD
PA450401	methadone	Chemical	ClinicalAnnotation	associated	PD	32407152

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
26752265	2016	Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.	70
12530083	2002	Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas.	40
20378690	2010	Genetic variants in selenoprotein genes increase risk of colorectal cancer.	40
16774913	2006	Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase.	35
17634480	2007	Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer.	35
17601350	2007	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	27
21172426	2011	Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.	27
16424062	2006	Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer.	25
19692168	2010	Genetic susceptibility to distinct bladder cancer subphenotypes.	25

Citation

Dessen P

TXNRD2 (thioredoxin reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42736/txnrd2