UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1)

2006-10-01  

Identity

HGNC
LOCATION
1q23.3
LOCUSID
ALIAS
AGX,AGX1,AGX2,SPAG2
FUSION GENES

Other Information

Locus ID:

NCBI: 6675
MIM: 602862
HGNC: 12457
Ensembl: ENSG00000117143

Variants:

dbSNP: 6675
ClinVar: 6675
TCGA: ENSG00000117143
COSMIC: UAP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117143ENST00000271469Q16222
ENSG00000117143ENST00000367924Q16222
ENSG00000117143ENST00000367925Q16222
ENSG00000117143ENST00000367926Q16222
ENSG00000117143ENST00000367926A0A140VKC0

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Amino sugar and nucleotide sugar metabolismKEGGko00520
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Nucleotide sugar biosynthesis, eukaryotesKEGGhsa_M00361
Nucleotide sugar biosynthesis, eukaryotesKEGGM00361
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Synthesis of UDP-N-acetyl-glucosamineREACTOMER-HSA-446210

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
252418962015UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation.32
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30

Citation

Dessen P

UAP1 (UDP-N-acetylglucosamine pyrophosphorylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43549/uap1