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UBA5 (ubiquitin like modifier activating enzyme 5)

Identity

Alias (NCBI)EIEE44
SCAR24
THIFP1
UBE1DC1
HGNC (Hugo) UBA5
HGNC Alias symbFLJ23251
HGNC Alias nameUBA5, ubiquitin-activating enzyme E1 homolog (yeast)
HGNC Previous nameUBE1DC1
HGNC Previous nameubiquitin-activating enzyme E1-domain containing 1
 ubiquitin-like modifier activating enzyme 5
LocusID (NCBI) 79876
Atlas_Id 46973
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 132654446 and ends at 132678107 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBA5   23230
Cards
Entrez_Gene (NCBI)UBA5  79876  ubiquitin like modifier activating enzyme 5
AliasesEIEE44; SCAR24; THIFP1; UBE1DC1
GeneCards (Weizmann)UBA5
Ensembl hg19 (Hinxton)ENSG00000081307 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081307 [Gene_View]  ENSG00000081307 [Sequence]  chr3:132654446-132678107 [Contig_View]  UBA5 [Vega]
ICGC DataPortalENSG00000081307
TCGA cBioPortalUBA5
AceView (NCBI)UBA5
Genatlas (Paris)UBA5
WikiGenes79876
SOURCE (Princeton)UBA5
Genetics Home Reference (NIH)UBA5
Genomic and cartography
GoldenPath hg38 (UCSC)UBA5  -     chr3:132654446-132678107 +  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBA5  -     3q22.1   [Description]    (hg19-Feb_2009)
GoldenPathUBA5 - 3q22.1 [CytoView hg19]  UBA5 - 3q22.1 [CytoView hg38]
ImmunoBaseENSG00000081307
genome Data Viewer NCBIUBA5 [Mapview hg19]  
OMIM610552   617132   617133   
Gene and transcription
Genbank (Entrez)AB154406 AI681654 AK026904 AK027563 AK056238
RefSeq transcript (Entrez)NM_001320210 NM_001321238 NM_001321239 NM_024818 NM_198329
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBA5
Alternative Splicing GalleryENSG00000081307
Gene ExpressionUBA5 [ NCBI-GEO ]   UBA5 [ EBI - ARRAY_EXPRESS ]   UBA5 [ SEEK ]   UBA5 [ MEM ]
Gene Expression Viewer (FireBrowse)UBA5 [ Firebrowse - Broad ]
GenevisibleExpression of UBA5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79876
GTEX Portal (Tissue expression)UBA5
Human Protein AtlasENSG00000081307-UBA5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZZ9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZZ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZZ9
Splice isoforms : SwissVarQ9GZZ9
PhosPhoSitePlusQ9GZZ9
Domains : Interpro (EBI)D-isomer_DH_CS1    ThiF_NAD_FAD-bd    Ubiquitin-activating_enz   
Domain families : Pfam (Sanger)ThiF (PF00899)   
Domain families : Pfam (NCBI)pfam00899   
Conserved Domain (NCBI)UBA5
DMDM Disease mutations79876
Blocks (Seattle)UBA5
PDB (RSDB)3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
PDB Europe3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
PDB (PDBSum)3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
PDB (IMB)3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
Structural Biology KnowledgeBase3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
SCOP (Structural Classification of Proteins)3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
CATH (Classification of proteins structures)3GUC    3H8V    5HKH    5IA8    5IAA    5L95    6H77    6H78    6H8C   
SuperfamilyQ9GZZ9
Human Protein Atlas [tissue]ENSG00000081307-UBA5 [tissue]
Peptide AtlasQ9GZZ9
HPRD15598
IPIIPI00015736   IPI00383579   IPI00945538   IPI00946703   IPI00945700   IPI00791004   IPI00967975   IPI00968261   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZZ9
IntAct (EBI)Q9GZZ9
FunCoupENSG00000081307
BioGRIDUBA5
STRING (EMBL)UBA5
ZODIACUBA5
Ontologies - Pathways
QuickGOQ9GZZ9
Ontology : AmiGOprotein binding  ATP binding  nucleus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  protein modification by small protein conjugation  regulation of intracellular estrogen receptor signaling pathway  response to endoplasmic reticulum stress  intracellular membrane-bounded organelle  metal ion binding  neuromuscular process  UFM1 activating enzyme activity  UFM1 activating enzyme activity  UFM1 activating enzyme activity  protein ufmylation  protein ufmylation  protein ufmylation  protein K69-linked ufmylation  
Ontology : EGO-EBIprotein binding  ATP binding  nucleus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  protein modification by small protein conjugation  regulation of intracellular estrogen receptor signaling pathway  response to endoplasmic reticulum stress  intracellular membrane-bounded organelle  metal ion binding  neuromuscular process  UFM1 activating enzyme activity  UFM1 activating enzyme activity  UFM1 activating enzyme activity  protein ufmylation  protein ufmylation  protein ufmylation  protein K69-linked ufmylation  
NDEx NetworkUBA5
Atlas of Cancer Signalling NetworkUBA5
Wikipedia pathwaysUBA5
Orthology - Evolution
OrthoDB79876
GeneTree (enSembl)ENSG00000081307
Phylogenetic Trees/Animal Genes : TreeFamUBA5
HOGENOMQ9GZZ9
Homologs : HomoloGeneUBA5
Homology/Alignments : Family Browser (UCSC)UBA5
Gene fusions - Rearrangements
Fusion : QuiverUBA5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBA5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBA5
dbVarUBA5
ClinVarUBA5
1000_GenomesUBA5 
Exome Variant ServerUBA5
GNOMAD BrowserENSG00000081307
Varsome BrowserUBA5
Genetic variants : HAPMAP79876
Genomic Variants (DGV)UBA5 [DGVbeta]
DECIPHERUBA5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBA5 
Mutations
ICGC Data PortalUBA5 
TCGA Data PortalUBA5 
Broad Tumor PortalUBA5
OASIS PortalUBA5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBA5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUBA5
Mutations and Diseases : HGMDUBA5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBA5
DgiDB (Drug Gene Interaction Database)UBA5
DoCM (Curated mutations)UBA5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBA5 (select a term)
intoGenUBA5
Cancer3DUBA5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610552    617132    617133   
Orphanet
DisGeNETUBA5
MedgenUBA5
Genetic Testing Registry UBA5
NextProtQ9GZZ9 [Medical]
TSGene79876
GENETestsUBA5
Target ValidationUBA5
Huge Navigator UBA5 [HugePedia]
snp3D : Map Gene to Disease79876
BioCentury BCIQUBA5
ClinGenUBA5
Clinical trials, drugs, therapy
Protein Interactions : CTD79876
Pharm GKB GenePA162407661
Clinical trialUBA5
Miscellaneous
canSAR (ICR)UBA5 (select the gene name)
HarmonizomeUBA5
DataMed IndexUBA5
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBA5
EVEXUBA5
GoPubMedUBA5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:41:17 CEST 2020

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