UBASH3B (ubiquitin associated and SH3 domain containing B)

2007-02-01  

Identity

HGNC
LOCATION
11q24.1
LOCUSID
ALIAS
STS-1,STS1,TULA-2,TULA2,p70
FUSION GENES

Other Information

Locus ID:

NCBI: 84959
MIM: 609201
HGNC: 29884
Ensembl: ENSG00000154127

Variants:

dbSNP: 84959
ClinVar: 84959
TCGA: ENSG00000154127
COSMIC: UBASH3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154127ENST00000284273Q8TF42

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
153885812005Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells.39
151594122004Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.38
205850422010A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets.27
237847752013Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis.24
181892692008TULA proteins regulate activity of the protein tyrosine kinase Syk.22
264496612016UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.19
259597152015STS-1 promotes IFN-α induced autophagy by activating the JAK1-STAT1 signaling pathway in B cells.12
265162272015Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice.9
267664432016Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.9

Citation

Dessen P

UBASH3B (ubiquitin associated and SH3 domain containing B)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45606/ubash3b