UBE2E3 (ubiquitin conjugating enzyme E2 E3)

2007-04-01  

Identity

HGNC
LOCATION
2q31.3
LOCUSID
ALIAS
UBCH9,UbcM2
FUSION GENES

Other Information

Locus ID:

NCBI: 10477
MIM: 604151
HGNC: 12479
Ensembl: ENSG00000170035

Variants:

dbSNP: 10477
ClinVar: 10477
TCGA: ENSG00000170035
COSMIC: UBE2E3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170035ENST00000392415Q969T4
ENSG00000170035ENST00000410062Q969T4
ENSG00000170035ENST00000602291R4GND1
ENSG00000170035ENST00000602303A0A1B0GX65
ENSG00000170035ENST00000602475R4GMM6
ENSG00000170035ENST00000602479R4GND1
ENSG00000170035ENST00000602499R4GN77
ENSG00000170035ENST00000602632R4GNG6
ENSG00000170035ENST00000602710Q969T4
ENSG00000170035ENST00000602959Q969T4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
253785862015The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2.13
186148082008The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells.9
298795502018Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence.0

Citation

Dessen P

UBE2E3 (ubiquitin conjugating enzyme E2 E3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46950/ube2e3