UBE2J2 (ubiquitin conjugating enzyme E2 J2)

2014-08-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
NCUBE-2,NCUBE2,PRO2121
FUSION GENES

Other Information

Locus ID:

NCBI: 118424
HGNC: 19268
Ensembl: ENSG00000160087

Variants:

dbSNP: 118424
ClinVar: 118424
TCGA: ENSG00000160087
COSMIC: UBE2J2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160087ENST00000347370A6NGS0
ENSG00000160087ENST00000349431Q8N2K1
ENSG00000160087ENST00000349431A0A024R075
ENSG00000160087ENST00000360466Q8N2K1
ENSG00000160087ENST00000360466A0A024R075
ENSG00000160087ENST00000400929A6NGS0
ENSG00000160087ENST00000400930Q8N2K1
ENSG00000160087ENST00000422076B1AMF1
ENSG00000160087ENST00000435198B1AMF0
ENSG00000160087ENST00000450390D6REN4
ENSG00000160087ENST00000464036D6RC43
ENSG00000160087ENST00000466752D6R9H0
ENSG00000160087ENST00000473215D6R9H0
ENSG00000160087ENST00000477894D6RA15
ENSG00000160087ENST00000488418D6REN4
ENSG00000160087ENST00000502382D6RB84
ENSG00000160087ENST00000503294D6R9H0
ENSG00000160087ENST00000509720D6RD90

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Parkinson's diseaseKEGGhsa05012
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
200613862010The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.57
250838002014The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation.6
287437402017Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.4
306581892019Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.2

Citation

Dessen P

UBE2J2 (ubiquitin conjugating enzyme E2 J2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54744/ube2j2