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UBE2L3 (ubiquitin-conjugating enzyme E2L 3)

Identity

Other namesE2-F1
L-UBC
UBCH7
UbcM4
HGNC (Hugo) UBE2L3
LocusID (NCBI) 7332
Location 22q11.21
Location_base_pair Starts at 21903736 and ends at 21978323 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UBE2L3   12488
Cards
Entrez_Gene (NCBI)UBE2L3  7332  ubiquitin-conjugating enzyme E2L 3
GeneCards (Weizmann)UBE2L3
Ensembl (Hinxton)ENSG00000185651 [Gene_View]  chr22:21903736-21978323 [Contig_View]  UBE2L3 [Vega]
ICGC DataPortalENSG00000185651
cBioPortalUBE2L3
AceView (NCBI)UBE2L3
Genatlas (Paris)UBE2L3
WikiGenes7332
SOURCE (Princeton)NM_001256355 NM_001256356 NM_003347 NM_198157
Genomic and cartography
GoldenPath (UCSC)UBE2L3  -  22q11.21   chr22:21903736-21978323 +  22q11.21   [Description]    (hg19-Feb_2009)
EnsemblUBE2L3 - 22q11.21 [CytoView]
Mapping of homologs : NCBIUBE2L3 [Mapview]
OMIM603721   
Gene and transcription
Genbank (Entrez)AJ000519 AK125396 AK291083 AK293179 AK299985
RefSeq transcript (Entrez)NM_001256355 NM_001256356 NM_003347 NM_198157
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004929430
Consensus coding sequences : CCDS (NCBI)UBE2L3
Cluster EST : UnigeneHs.108104 [ NCBI ]
CGAP (NCI)Hs.108104
Alternative Splicing : Fast-db (Paris)GSHG0019859
Alternative Splicing GalleryENSG00000185651
Gene ExpressionUBE2L3 [ NCBI-GEO ]     UBE2L3 [ SEEK ]   UBE2L3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68036 (Uniprot)
NextProtP68036  [Medical]
With graphics : InterProP68036
Splice isoforms : SwissVarP68036 (Swissvar)
Catalytic activity : Enzyme6.3.2.19 [ Enzyme-Expasy ]   6.3.2.196.3.2.19 [ IntEnz-EBI ]   6.3.2.19 [ BRENDA ]   6.3.2.19 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2 [organisation]   UBQ-conjugating_AS [organisation]   UBQ-conjugating_enzyme/RWD [organisation]  
Related proteins : CluSTrP68036
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7332
Blocks (Seattle)P68036
PDB (SRS)1C4Z    1FBV    3SQV    3SY2   
PDB (PDBSum)1C4Z    1FBV    3SQV    3SY2   
PDB (IMB)1C4Z    1FBV    3SQV    3SY2   
PDB (RSDB)1C4Z    1FBV    3SQV    3SY2   
Human Protein AtlasENSG00000185651 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP68036
HPRD04762
IPIIPI00021347   IPI00909975   IPI00909773   
Protein Interaction databases
DIP (DOE-UCLA)P68036
IntAct (EBI)P68036
FunCoupENSG00000185651
BioGRIDUBE2L3
InParanoidP68036
Interologous Interaction database P68036
IntegromeDBUBE2L3
STRING (EMBL)UBE2L3
Ontologies - Pathways
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  transcription coactivator activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  ubiquitin-dependent protein catabolic process  cell proliferation  protein ubiquitination  acid-amino acid ligase activity  enzyme binding  ubiquitin protein ligase binding  poly(A) RNA binding  extracellular vesicular exosome  protein K11-linked ubiquitination  cellular response to steroid hormone stimulus  cellular response to glucocorticoid stimulus  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  transcription coactivator activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  ubiquitin-dependent protein catabolic process  cell proliferation  protein ubiquitination  acid-amino acid ligase activity  enzyme binding  ubiquitin protein ligase binding  poly(A) RNA binding  extracellular vesicular exosome  protein K11-linked ubiquitination  cellular response to steroid hormone stimulus  cellular response to glucocorticoid stimulus  
Pathways : KEGGUbiquitin mediated proteolysis    Parkinson's disease   
Protein Interaction DatabaseUBE2L3
Wikipedia pathwaysUBE2L3
Gene fusion - rearrangments
Rearrangement : COSMICUBE2L3 [22q11.21]  -  KRAS [12p12.1]  
  [COSF1298] [COSF1299] 
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)UBE2L3
snp3D : Map Gene to Disease7332
SNP (GeneSNP Utah)UBE2L3
SNP : HGBaseUBE2L3
Genetic variants : HAPMAPUBE2L3
Exome VariantUBE2L3
1000_GenomesUBE2L3 
ICGC programENSG00000185651 
Somatic Mutations in Cancer : COSMICUBE2L3 
CONAN: Copy Number AnalysisUBE2L3 
Mutations and Diseases : HGMDUBE2L3
Genomic VariantsUBE2L3  UBE2L3 [DGVbeta]
dbVarUBE2L3
ClinVarUBE2L3
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603721   
MedgenUBE2L3
GENETestsUBE2L3
Disease Genetic AssociationUBE2L3
Huge Navigator UBE2L3 [HugePedia]  UBE2L3 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneUBE2L3
Homology/Alignments : Family Browser (UCSC)UBE2L3
Phylogenetic Trees/Animal Genes : TreeFamUBE2L3
Chemical/Protein Interactions : CTD7332
Chemical/Pharm GKB GenePA37137
Clinical trialUBE2L3
Cancer Resource (Charite)ENSG00000185651
Other databases
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
CoreMineUBE2L3
iHOPUBE2L3
OncoSearchUBE2L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:51:28 CEST 2014

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