Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UBE2L3 (ubiquitin conjugating enzyme E2L 3)

Identity

Other namesE2-F1
L-UBC
UBCH7
UbcM4
HGNC (Hugo) UBE2L3
LocusID (NCBI) 7332
Atlas_Id 46591
Location 22q11.21
Location_base_pair Starts at 21903736 and ends at 21978323 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
UBE2L3 22q11.21 / KRAS -

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2L3   12488
Cards
Entrez_Gene (NCBI)UBE2L3  7332  ubiquitin conjugating enzyme E2L 3
GeneCards (Weizmann)UBE2L3
Ensembl hg19 (Hinxton)ENSG00000185651 [Gene_View]  chr22:21903736-21978323 [Contig_View]  UBE2L3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185651 [Gene_View]  chr22:21903736-21978323 [Contig_View]  UBE2L3 [Vega]
ICGC DataPortalENSG00000185651
TCGA cBioPortalUBE2L3
AceView (NCBI)UBE2L3
Genatlas (Paris)UBE2L3
WikiGenes7332
SOURCE (Princeton)UBE2L3
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2L3  -     chr22:21903736-21978323 +  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2L3  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblUBE2L3 - 22q11.21 [CytoView hg19]  UBE2L3 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBIUBE2L3 [Mapview hg19]  UBE2L3 [Mapview hg38]
OMIM603721   
Gene and transcription
Genbank (Entrez)AJ000519 AK125396 AK291083 AK293179 AK299985
RefSeq transcript (Entrez)NM_001256355 NM_001256356 NM_003347 NM_198157
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)UBE2L3
Cluster EST : UnigeneHs.108104 [ NCBI ]
CGAP (NCI)Hs.108104
Alternative Splicing : Fast-db (Paris)GSHG0019859
Alternative Splicing GalleryENSG00000185651
Gene ExpressionUBE2L3 [ NCBI-GEO ]     UBE2L3 [ SEEK ]   UBE2L3 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7332
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68036 (Uniprot)
NextProtP68036  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68036
Splice isoforms : SwissVarP68036 (Swissvar)
Catalytic activity : Enzyme6.3.2.19 [ Enzyme-Expasy ]   6.3.2.19 [ Enzyme-SRS ]   6.3.2.19 [ IntEnz-EBI ]   6.3.2.19 [ PRIAM ]   6.3.2.19 [ BRENDA ]   6.3.2.19 [ KEGG ]   6.3.2.19 [ IUBMB ]
PhosPhoSitePlusP68036
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7332
Blocks (Seattle)UBE2L3
PDB (SRS)1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
PDB (PDBSum)1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
PDB (IMB)1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
PDB (RSDB)1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
Structural Biology KnowledgeBase1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
SCOP (Structural Classification of Proteins)1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
CATH (Classification of proteins structures)1C4Z    1FBV    3SQV    3SY2    4Q5E    4Q5H   
Human Protein AtlasENSG00000185651
Peptide AtlasP68036
HPRD04762
IPIIPI00021347   IPI00909975   IPI00909773   
Protein Interaction databases
DIP (DOE-UCLA)P68036
IntAct (EBI)P68036
FunCoupENSG00000185651
BioGRIDUBE2L3
IntegromeDBUBE2L3
STRING (EMBL)UBE2L3
ZODIACUBE2L3
Ontologies - Pathways
QuickGOP68036
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  transcription coactivator activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  ubiquitin-dependent protein catabolic process  cell proliferation  protein ubiquitination  enzyme binding  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  cell cycle phase transition  poly(A) RNA binding  positive regulation of ubiquitin-protein transferase activity  ubiquitin conjugating enzyme activity  extracellular exosome  protein K11-linked ubiquitination  cellular response to steroid hormone stimulus  cellular response to glucocorticoid stimulus  ubiquitin-protein transferase activator activity  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  transcription coactivator activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription, DNA-templated  regulation of transcription, DNA-templated  cellular protein modification process  ubiquitin-dependent protein catabolic process  cell proliferation  protein ubiquitination  enzyme binding  positive regulation of protein ubiquitination  ubiquitin protein ligase binding  cell cycle phase transition  poly(A) RNA binding  positive regulation of ubiquitin-protein transferase activity  ubiquitin conjugating enzyme activity  extracellular exosome  protein K11-linked ubiquitination  cellular response to steroid hormone stimulus  cellular response to glucocorticoid stimulus  ubiquitin-protein transferase activator activity  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGUbiquitin mediated proteolysis    Parkinson's disease   
Protein Interaction DatabaseUBE2L3
Atlas of Cancer Signalling NetworkUBE2L3
Wikipedia pathwaysUBE2L3
Orthology - Evolution
OrthoDB7332
GeneTree (enSembl)ENSG00000185651
Phylogenetic Trees/Animal Genes : TreeFamUBE2L3
Homologs : HomoloGeneUBE2L3
Homology/Alignments : Family Browser (UCSC)UBE2L3
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerUBE2L3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2L3
dbVarUBE2L3
ClinVarUBE2L3
1000_GenomesUBE2L3 
Exome Variant ServerUBE2L3
Exome Aggregation Consortium (ExAC)ENSG00000185651
SNP (GeneSNP Utah)UBE2L3
SNP : HGBaseUBE2L3
Genetic variants : HAPMAPUBE2L3
Genomic Variants (DGV)UBE2L3 [DGVbeta]
Mutations
ICGC Data PortalUBE2L3 
TCGA Data PortalUBE2L3 
Tumor PortalUBE2L3
TCGA Copy Number PortalUBE2L3
Somatic Mutations in Cancer : COSMICUBE2L3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2L3
DgiDB (Drug Gene Interaction Database)UBE2L3
DoCM (Curated mutations)UBE2L3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2L3 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)22:21903736-21978323
CONAN: Copy Number AnalysisUBE2L3 
Mutations and Diseases : HGMDUBE2L3
OMIM603721   
MedgenUBE2L3
NextProtP68036 [Medical]
TSGene7332
GENETestsUBE2L3
Huge Navigator UBE2L3 [HugePedia]  UBE2L3 [HugeCancerGEM]
snp3D : Map Gene to Disease7332
BioCentury BCIQUBE2L3
General knowledge
Chemical/Protein Interactions : CTD7332
Chemical/Pharm GKB GenePA37137
Clinical trialUBE2L3
Other databases
Probes
Litterature
PubMed195 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2L3
GoPubMedUBE2L3
iHOPUBE2L3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:42:27 CET 2016

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