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UBE2T (ubiquitin conjugating enzyme E2 T)

Identity

Alias_namesubiquitin-conjugating enzyme E2T
Alias_symbol (synonym)HSPC150
FANCT
Other aliasPIG50
HGNC (Hugo) UBE2T
LocusID (NCBI) 29089
Atlas_Id 50427
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 202331657 and ends at 202341966 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBE2T (1q32.1) / ATP5B (12q13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 1 ]
  Fanconi anemia

External links

Nomenclature
HGNC (Hugo)UBE2T   25009
LRG (Locus Reference Genomic)LRG_1169
Cards
Entrez_Gene (NCBI)UBE2T  29089  ubiquitin conjugating enzyme E2 T
AliasesFANCT; HSPC150; PIG50
GeneCards (Weizmann)UBE2T
Ensembl hg19 (Hinxton)ENSG00000077152 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000077152 [Gene_View]  ENSG00000077152 [Sequence]  chr1:202331657-202341966 [Contig_View]  UBE2T [Vega]
ICGC DataPortalENSG00000077152
TCGA cBioPortalUBE2T
AceView (NCBI)UBE2T
Genatlas (Paris)UBE2T
WikiGenes29089
SOURCE (Princeton)UBE2T
Genetics Home Reference (NIH)UBE2T
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2T  -     chr1:202331657-202341966 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2T  -     1q32.1   [Description]    (hg19-Feb_2009)
GoldenPathUBE2T - 1q32.1 [CytoView hg19]  UBE2T - 1q32.1 [CytoView hg38]
ImmunoBaseENSG00000077152
Mapping of homologs : NCBIUBE2T [Mapview hg19]  UBE2T [Mapview hg38]
OMIM610538   616435   
Gene and transcription
Genbank (Entrez)AB032931 AF160215 AF161499 AK000504 AY542309
RefSeq transcript (Entrez)NM_001310326 NM_014176
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2T
Cluster EST : UnigeneHs.5199 [ NCBI ]
CGAP (NCI)Hs.5199
Alternative Splicing GalleryENSG00000077152
Gene ExpressionUBE2T [ NCBI-GEO ]   UBE2T [ EBI - ARRAY_EXPRESS ]   UBE2T [ SEEK ]   UBE2T [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2T [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29089
GTEX Portal (Tissue expression)UBE2T
Human Protein AtlasENSG00000077152-UBE2T [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPD8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPD8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPD8
Splice isoforms : SwissVarQ9NPD8
PhosPhoSitePlusQ9NPD8
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2T
DMDM Disease mutations29089
Blocks (Seattle)UBE2T
PDB (RSDB)1YH2    4CCG    5NGZ    5OJJ   
PDB Europe1YH2    4CCG    5NGZ    5OJJ   
PDB (PDBSum)1YH2    4CCG    5NGZ    5OJJ   
PDB (IMB)1YH2    4CCG    5NGZ    5OJJ   
Structural Biology KnowledgeBase1YH2    4CCG    5NGZ    5OJJ   
SCOP (Structural Classification of Proteins)1YH2    4CCG    5NGZ    5OJJ   
CATH (Classification of proteins structures)1YH2    4CCG    5NGZ    5OJJ   
SuperfamilyQ9NPD8
Human Protein Atlas [tissue]ENSG00000077152-UBE2T [tissue]
Peptide AtlasQ9NPD8
HPRD13704
IPIIPI00023087   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPD8
IntAct (EBI)Q9NPD8
FunCoupENSG00000077152
BioGRIDUBE2T
STRING (EMBL)UBE2T
ZODIACUBE2T
Ontologies - Pathways
QuickGOQ9NPD8
Ontology : AmiGOchromatin binding  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleoplasm  nucleolus  DNA repair  protein monoubiquitination  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  protein ubiquitination  ubiquitin protein ligase binding  protein K29-linked ubiquitination  interstrand cross-link repair  protein K27-linked ubiquitination  protein autoubiquitination  ubiquitin conjugating enzyme activity  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  protein K6-linked ubiquitination  
Ontology : EGO-EBIchromatin binding  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleus  nucleus  nucleoplasm  nucleolus  DNA repair  protein monoubiquitination  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  protein ubiquitination  ubiquitin protein ligase binding  protein K29-linked ubiquitination  interstrand cross-link repair  protein K27-linked ubiquitination  protein autoubiquitination  ubiquitin conjugating enzyme activity  ubiquitin conjugating enzyme activity  protein K63-linked ubiquitination  protein K48-linked ubiquitination  protein K11-linked ubiquitination  protein K6-linked ubiquitination  
Pathways : KEGGFanconi anemia pathway   
NDEx NetworkUBE2T
Atlas of Cancer Signalling NetworkUBE2T
Wikipedia pathwaysUBE2T
Orthology - Evolution
OrthoDB29089
GeneTree (enSembl)ENSG00000077152
Phylogenetic Trees/Animal Genes : TreeFamUBE2T
HOGENOMQ9NPD8
Homologs : HomoloGeneUBE2T
Homology/Alignments : Family Browser (UCSC)UBE2T
Gene fusions - Rearrangements
Fusion : QuiverUBE2T
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2T [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2T
dbVarUBE2T
ClinVarUBE2T
1000_GenomesUBE2T 
Exome Variant ServerUBE2T
ExAC (Exome Aggregation Consortium)ENSG00000077152
GNOMAD BrowserENSG00000077152
Varsome BrowserUBE2T
Genetic variants : HAPMAP29089
Genomic Variants (DGV)UBE2T [DGVbeta]
DECIPHERUBE2T [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2T 
Mutations
ICGC Data PortalUBE2T 
TCGA Data PortalUBE2T 
Broad Tumor PortalUBE2T
OASIS PortalUBE2T [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2T  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUBE2T
Mutations and Diseases : HGMDUBE2T
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2T
DgiDB (Drug Gene Interaction Database)UBE2T
DoCM (Curated mutations)UBE2T (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2T (select a term)
intoGenUBE2T
Cancer3DUBE2T(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610538    616435   
Orphanet634   
DisGeNETUBE2T
MedgenUBE2T
Genetic Testing Registry UBE2T
NextProtQ9NPD8 [Medical]
TSGene29089
GENETestsUBE2T
Target ValidationUBE2T
Huge Navigator UBE2T [HugePedia]
snp3D : Map Gene to Disease29089
BioCentury BCIQUBE2T
ClinGenUBE2T
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29089
Chemical/Pharm GKB GenePA142670655
Clinical trialUBE2T
Miscellaneous
canSAR (ICR)UBE2T (select the gene name)
DataMed IndexUBE2T
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2T
EVEXUBE2T
GoPubMedUBE2T
iHOPUBE2T
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:14:00 CET 2019
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