UBE2W (ubiquitin conjugating enzyme E2 W)

2012-06-01  

Identity

HGNC
LOCATION
8q21.11
LOCUSID
ALIAS
UBC-16,UBC16
FUSION GENES

Other Information

Locus ID:

NCBI: 55284
MIM: 614277
HGNC: 25616
Ensembl: ENSG00000104343

Variants:

dbSNP: 55284
ClinVar: 55284
TCGA: ENSG00000104343
COSMIC: UBE2W

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104343ENST00000419880X6REH9
ENSG00000104343ENST00000422906E5RG25
ENSG00000104343ENST00000517608Q96B02
ENSG00000104343ENST00000519255E5RG25
ENSG00000104343ENST00000519277E5RG25
ENSG00000104343ENST00000523278H0YB73
ENSG00000104343ENST00000602593Q96B02
ENSG00000104343ENST00000650817X6REH9
ENSG00000104343ENST00000651945Q96B02
ENSG00000104343ENST00000651945A0A024R7X9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365933102023Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W.6
365933102023Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W.6
339310242021Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.3
339310242021Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.3
315186132020N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.23
315186132020N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.23
271855772016Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.10
271855772016Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage.10
254365192015Intrinsic disorder drives N-terminal ubiquitination by Ube2w.44
261013722015TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.62
254365192015Intrinsic disorder drives N-terminal ubiquitination by Ube2w.44
261013722015TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.62
236966362013The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.53
236966362013The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.53
212293262011UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.20

Citation

Dessen P

UBE2W (ubiquitin conjugating enzyme E2 W)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52739/ube2w