UBE2Z (ubiquitin conjugating enzyme E2 Z)

2017-08-01  

Identity

HGNC
LOCATION
17q21.32
LOCUSID
ALIAS
HOYS7,USE1
FUSION GENES

Other Information

Locus ID:

NCBI: 65264
MIM: 611362
HGNC: 25847
Ensembl: ENSG00000159202

Variants:

dbSNP: 65264
ClinVar: 65264
TCGA: ENSG00000159202
COSMIC: UBE2Z

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159202ENST00000360943Q9H832
ENSG00000159202ENST00000504684I3L3V3
ENSG00000159202ENST00000506498H0Y9X8
ENSG00000159202ENST00000508468D6RB11
ENSG00000159202ENST00000511373I3L4C5
ENSG00000159202ENST00000514948I3L286

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175977592007Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.122
288401292017Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.5
171606262007Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).4
266028832015Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.3
283762052017Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis.2

Citation

Dessen P

UBE2Z (ubiquitin conjugating enzyme E2 Z)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57024/ube2z