UBE4A (ubiquitination factor E4A)

2007-04-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
E4,UBOX2,UFD2
FUSION GENES

Other Information

Locus ID:

NCBI: 9354
MIM: 603753
HGNC: 12499
Ensembl: ENSG00000110344

Variants:

dbSNP: 9354
ClinVar: 9354
TCGA: ENSG00000110344
COSMIC: UBE4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110344ENST00000252108Q14139
ENSG00000110344ENST00000431736Q14139
ENSG00000110344ENST00000545354B7Z7P0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
180696752008Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease.10
294991382018The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.10
150199852004Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues.9
278628412017The ubiquitin ligase UBE4A inhibits prostate cancer progression by targeting interleukin-like EMT inducer (ILEI).6
175533432007[Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues].5
156116592004Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation.4
289633762017Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma.0

Citation

Dessen P

UBE4A (ubiquitination factor E4A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47051/ube4a