UBTF (upstream binding transcription factor)

2007-02-01  

Identity

HGNC
UBTF
LOCATION
17q21.31
LOCUSID
7343
ALIAS
CONDBA,NOR-90,UBF,UBF-1,UBF1,UBF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7343
MIM: 600673
HGNC: 12511
Ensembl: ENSG00000108312

Variants:

dbSNP: 7343
ClinVar: 7343
TCGA: ENSG00000108312
COSMIC: UBTF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108312ENST00000302904P17480
ENSG00000108312ENST00000343638P17480
ENSG00000108312ENST00000393606P17480
ENSG00000108312ENST00000436088P17480
ENSG00000108312ENST00000526094P17480
ENSG00000108312ENST00000527034E9PKP7
ENSG00000108312ENST00000529373E9PLT2
ENSG00000108312ENST00000529383P17480
ENSG00000108312ENST00000529947H0YDH7
ENSG00000108312ENST00000530828E9PMM2
ENSG00000108312ENST00000533177P17480

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Promoter OpeningREACTOMER-HSA-73728
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
RNA Polymerase I Transcription TerminationREACTOMER-HSA-73863
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
155989842005UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery.82
176997512007Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells.72
152825432004MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation.62
168584082006UBF activates RNA polymerase I transcription by stimulating promoter escape.42
169242432006Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation.39
159705932005TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.30
235918142013Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription.21
223932352012A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation.20
211778592011hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF).19
254523142015A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.17

Citation

Dessen P

UBTF (upstream binding transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45793/ubtf