UCHL3 (ubiquitin C-terminal hydrolase L3)

2003-11-01  

Identity

HGNC
LOCATION
13q22.2
LOCUSID
ALIAS
UCH-L3
FUSION GENES

Other Information

Locus ID:

NCBI: 7347
MIM: 603090
HGNC: 12515
Ensembl: ENSG00000118939

Variants:

dbSNP: 7347
ClinVar: 7347
TCGA: ENSG00000118939
COSMIC: UCHL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118939ENST00000377595P15374
ENSG00000118939ENST00000377595A0A140VJZ4
ENSG00000118939ENST00000419068Q5TBK7
ENSG00000118939ENST00000618773A0A087WTB8

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
155315862005Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate.75
164023892006Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.45
190470592009Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations.21
194764992009Untangling the folding mechanism of the 5(2)-knotted protein UCH-L3.16
217626962011Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).13
298984042018UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.12
191547702009Ubiquitin dimers control the hydrolase activity of UCH-L3.7
251948102014Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.7
226794852012A novel RNAi lethality rescue screen to identify regulators of adipogenesis.4
305594502018The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.4

Citation

Dessen P

UCHL3 (ubiquitin C-terminal hydrolase L3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42762/uchl3