UCHL5 (ubiquitin C-terminal hydrolase L5)

2007-02-01 Affiliation

Identity

HGNC

UCHL5

LOCATION

1q31.2

LOCUSID

51377

ALIAS

CGI-70,INO80R,UCH-L5,UCH37

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51377
MIM: 610667
HGNC: 19678
Ensembl: ENSG00000116750

Variants:

dbSNP: 51377
ClinVar: 51377
TCGA: ENSG00000116750
COSMIC: UCHL5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116750	ENST00000367448	Q9Y5K5
ENSG00000116750	ENST00000367449	Q9Y5K5
ENSG00000116750	ENST00000367450	Q5LJA9
ENSG00000116750	ENST00000367451	Q5LJA5
ENSG00000116750	ENST00000367454	Q9Y5K5
ENSG00000116750	ENST00000367455	Q9Y5K5
ENSG00000116750	ENST00000416915	H0Y4K0
ENSG00000116750	ENST00000417752	Q5LJB1
ENSG00000116750	ENST00000420791	H0Y6Y4
ENSG00000116750	ENST00000421683	Q5LJB0
ENSG00000116750	ENST00000443327	H0Y4E0
ENSG00000116750	ENST00000449480	H0Y636

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Signal Transduction	REACTOME	R-HSA-162582
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling activates SMADs	REACTOME	R-HSA-2173789
Downregulation of TGF-beta receptor signaling	REACTOME	R-HSA-2173788
Deubiquitination	REACTOME	R-HSA-5688426
UCH proteinases	REACTOME	R-HSA-5689603

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16906146	2006	Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.	144
24319254	2014	A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.	113
16990800	2006	A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.	111
17139257	2006	hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.	99
16027725	2005	The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling.	67
18922472	2008	Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.	64
16402389	2006	Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.	45
25702870	2015	Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G.	38
25702872	2015	Structural basis for the activation and inhibition of the UCH37 deubiquitylase.	38
28598414	2017	Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.	28

Citation

Dessen P

UCHL5 (ubiquitin C-terminal hydrolase L5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46496/uchl5